{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:25:14Z","timestamp":1775064314989,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,12,9]],"date-time":"2004-12-09T00:00:00Z","timestamp":1102550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Using two models of filarial infection in which <jats:italic>Brugia malayi<\/jats:italic> microfilariae (Mf) are contained in distinct anatomical compartments, in blood or tissue sites, we have demonstrated a critical role for eotaxin\u20101 in parasite clearance. In the first model, implantation of adult <jats:italic>B.\u2004malayi<\/jats:italic> into the peritoneal cavity of eotaxin\u20101<jats:sup>\u2013\/\u2013<\/jats:sup> mice resulted in increased Mf survival associated with a dramatic reduction in peritoneal cavity eosinophilic infiltration. In the second model Mf were injected intravenously into eotaxin\u20101<jats:sup>\u2013\/\u2013<\/jats:sup> mice; Mf clearance from the blood was more rapid than in wild\u2010type mice and was associated with a pronounced blood eosinophilia, resulting from the inability of eosinophils to migrate to tissue sites in the absence of eotaxin\u20101. (Eotaxin\u20101 + IL\u20105)<jats:sup>\u2013\/\u2013<\/jats:sup> mice had extended Mf survival in the blood and significantly reduced blood eosinophil levels. Interestingly, rapid clearance of a secondary Mf infection following immunization was unaltered in either eotaxin\u20101<jats:sup>\u2013\/\u2013<\/jats:sup> mice or (eotaxin\u20101 + IL\u20105)<jats:sup>\u2013\/\u2013<\/jats:sup> mice. Eosinophil peroxidase levels were high during primary, but not secondary infection, suggesting that eosinophil degranulation is important during primary Mf clearance. Thus, our data show that the presence of eosinophils is critical for innate clearance of <jats:italic>B.\u2004malayi <\/jats:italic>Mf infection, whereas rapid clearance of secondary infections is independent of both eotaxin\u20101 and IL\u20105.<\/jats:p>","DOI":"10.1002\/eji.200425541","type":"journal-article","created":{"date-parts":[[2004,12,9]],"date-time":"2004-12-09T10:32:30Z","timestamp":1102588350000},"page":"189-197","source":"Crossref","is-referenced-by-count":47,"title":["Eotaxin\u20101\u2010regulated eosinophils have a critical role in innate immunity against experimental <i>Brugia malayi<\/i> infection"],"prefix":"10.1002","volume":"35","author":[{"given":"Jonathan\u2004E.","family":"Simons","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc\u2004E.","family":"Rothenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel\u2004A.","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,12,16]]},"reference":[{"issue":"1","key":"e_1_2_7_1_2","first-page":"41","article-title":"Eosinophils and parasites.","volume":"66","author":"Capron M.","year":"1991","journal-title":"Ann. Parasitol. Hum. Comp."},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(97)01102-X"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1992.tb01415.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2001.790117.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.19.8960"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.10.5839"},{"key":"e_1_2_7_7_2","doi-asserted-by":"crossref","first-page":"5436","DOI":"10.4049\/jimmunol.160.11.5436","article-title":"IL\u20105\u2010dependent immunity to microfilariae is independent of IL\u20104 in a mouse model of onchocerciasis.","volume":"160","author":"Hogarth P. J.","year":"1998","journal-title":"J. Immunol."},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/12.6.899"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.5.2513-2517.2000"},{"key":"e_1_2_7_10_2","doi-asserted-by":"crossref","first-page":"205","DOI":"10.4049\/jimmunol.153.1.205","article-title":"IL\u20104\u2010 and IL\u20105\u2010dependent protective immunity to Onchocerca volvulus infective larvae in BALB\/cBYJ mice.","volume":"153","author":"Lange A. M.","year":"1994","journal-title":"J. Immunol."},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.6.3651-3656.2000"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2003.09.001"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1999.61.14"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1006\/clim.1999.4829"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1006\/exmp.2002.2439"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200204)32:4<1114::AID-IMMU1114>3.0.CO;2-B"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000053713"},{"key":"e_1_2_7_18_2","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.4049\/jimmunol.128.4.1792","article-title":"Soluble Brugia malayi microfilarial antigens protect mice against challenge by an antibody\u2010dependent mechanism.","volume":"128","author":"Kazura J. W.","year":"1982","journal-title":"J. Immunol."},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1006\/expr.1993.1023"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.5.1871"},{"key":"e_1_2_7_21_2","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.4049\/jimmunol.144.8.3166","article-title":"In vitro killing of microfilariae of Brugia pahangi and Brugia malayi by eosinophil granule proteins.","volume":"144","author":"Hamann K. J.","year":"1990","journal-title":"J. Immunol."},{"key":"e_1_2_7_22_2","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.4049\/jimmunol.127.4.1611","article-title":"Cellular killing of microfilariae of Onchocerca volvulus: eosinophil and neutrophil\u2010mediated immune serum\u2010dependent destruction.","volume":"127","author":"Greene B. M.","year":"1981","journal-title":"J. Immunol."},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000065847"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80414-8"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1006\/expr.1996.0034"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1998.00620.x"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8125"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199805283382206"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70281-2"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.11.5730"},{"key":"e_1_2_7_31_2","first-page":"51","article-title":"Deposition of eosinophil granule major basic protein onto microfilariae of Onchocerca volvulus in the skin of patients treated with diethylcarbamazine.","volume":"50","author":"Kephart G. M.","year":"1984","journal-title":"Lab. Invest."},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1006\/expr.1994.1006"},{"key":"e_1_2_7_33_2","doi-asserted-by":"crossref","first-page":"3826","DOI":"10.1182\/blood.V89.10.3826","article-title":"Lack of Fc\u2010epsilon receptors on murine eosinophils: implications for the functional significance of elevated IgE and eosinophils in parasitic infections.","volume":"89","author":"de Andres B.","year":"1997","journal-title":"Blood"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.8.4544"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.11.6447"},{"key":"e_1_2_7_36_2","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.4049\/jimmunol.153.3.1216","article-title":"Adult and microfilarial stages of the filarial parasite Brugia malayi stimulate contrasting cytokine and Ig isotype responses in BALB\/c mice.","volume":"153","author":"Lawrence R. A.","year":"1994","journal-title":"J. Immunol."},{"key":"e_1_2_7_37_2","unstructured":"Maizels R. M. Blaxter M. L. Selkirk M. E.andRobertson B. D. Parasite antigens parasite genes. A laboratory manual for molecular parasitology.Cambridge University Press Cambridge1991."},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.118600"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1759(02)00014-5"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.200425541","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.200425541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T21:14:41Z","timestamp":1696972481000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.200425541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12,16]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["10.1002\/eji.200425541"],"URL":"https:\/\/doi.org\/10.1002\/eji.200425541","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12,16]]}}}