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In contrast, only a twofold increase in NKG2C mRNA is noted. The addition of TGF\u2010\u03b2, but not IL\u201010, IL\u201012 or IL\u201015, leads to a further increase in cell membrane expression of these receptors, as well as a \u223c6\u2010fold increase in mRNA for both chains. TGF\u2010\u03b2 also increases CD94\/NKG2A expression on memory CD8 T\u2004cells that are re\u2010exposed to antigen. The effect of TGF\u2010\u03b2 on increasing CD94\/NKG2A expression on both naive and memory CD8 T\u2004cells occurs only when there is a concurrent stimulation through the TCR. In contrast, TGF\u2010\u03b2 does not increase expression of CD94\/NKG2A on resting or activated NK cells. We also show by using purified CD8 T\u2004cells, that TGF\u2010\u03b2 acts directly on these cells. These results implicate a role for both antigen and TGF\u2010\u03b2 in increasing expression of inhibitory CD94\/NKG2A receptors on CD8 T\u2004cells.<\/jats:p>","DOI":"10.1002\/eji.200425735","type":"journal-article","created":{"date-parts":[[2005,2,15]],"date-time":"2005-02-15T16:49:17Z","timestamp":1108486157000},"page":"766-775","source":"Crossref","is-referenced-by-count":37,"title":["The role of TCR stimulation and TGF\u2010\u03b2 in controlling the expression of CD94\/NKG2A receptors on CD8 T\u2004cells"],"prefix":"10.1002","volume":"35","author":[{"given":"Anasuya","family":"Gunturi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rance\u2004E.","family":"Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Crossley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Forman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,22]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.10.1841"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.12.1801"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/35869"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90550-9"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199801)28:01<264::AID-IMMU264>3.0.CO;2-O"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/35642"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.10.5277"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.8.4219"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1999.00833.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200201250-00008"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00427-2"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.4.1737"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.3.1444"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni757"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.2.693"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.3.1172"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.10.4864"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199901)29:01<23::AID-IMMU23>3.0.CO;2-Y"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.163.5.1037"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1991.tb17267.x"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1991.5530090502"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.166.4.991"},{"key":"e_1_2_7_23_2","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.4049\/jimmunol.146.10.3289","article-title":"Regulation of lymphokine\u2010activated killer activity and pore\u2010forming protein gene expression in human peripheral blood CD8+ T\u2004lymphocytes. 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