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We demonstrate here that persistent antigen suppressed IL\u20107R\u03b1 expression and this correlated with T cell exhaustion and reduced expression of the anti\u2010apoptotic molecule B cell leukemia\/lymphoma 2 (Bcl\u20102). In contrast, exposure to short\u2010lived antigen only temporarily suppressed IL\u20107R\u03b1 expression, failed to induce T cell exhaustion, and primed T cells. Persistent antigen also suppressed IL\u20107R\u03b1 expression on primed T cells and this correlated with exhaustion of a previously stable primed T cell population. These findings suggest that antigen longevity regulates T cell fate.<\/jats:p>","DOI":"10.1002\/eji.200425828","type":"journal-article","created":{"date-parts":[[2005,2,22]],"date-time":"2005-02-22T09:48:13Z","timestamp":1109065693000},"page":"738-745","source":"Crossref","is-referenced-by-count":134,"title":["Inverse correlation between IL\u20107 receptor expression and CD8 T cell exhaustion during persistent antigen stimulation"],"prefix":"10.1002","volume":"35","author":[{"given":"Karl\u2004S.","family":"Lang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Recher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander\u2004A.","family":"Navarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola\u2004L.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"L\u00f6hning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Junt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2004Christian","family":"Probst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Hengartner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf\u2004M.","family":"Zinkernagel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,22]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1332709100"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.21.11964"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.13.040195.000333"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(02)02326-8"},{"key":"e_1_2_7_5_2","doi-asserted-by":"crossref","first-page":"3074","DOI":"10.4049\/jimmunol.157.7.3074","article-title":"Exhaustion of CTL memory and recrudescence of viremia in lymphocytic choriomeningitis virus\u2010infected MHC class II\u2010deficient mice and B cell\u2010deficient mice.","volume":"157","author":"Thomsen A. 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