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Our analysis of these novel TNF\u2010knockout mice supports the previously disputed notion of the involvement of TNF\u2010TNFR1 signaling in PP organogenesis. Availability of TNF\u2010knockout strains both with and without PP enables more definitive studies concerning the roles of TNF and PP in various immune functions and disease conditions. Here, we report that systemic ablation of TNF, but not the presence of PP <jats:italic>per se<\/jats:italic>, is critical for protection against intestinal <jats:italic>Listeria<\/jats:italic> infection in mice.<\/jats:p>","DOI":"10.1002\/eji.200526119","type":"journal-article","created":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T10:20:09Z","timestamp":1113560409000},"page":"1592-1600","source":"Crossref","is-referenced-by-count":66,"title":["Novel tumor necrosis factor\u2010knockout mice that lack Peyer's patches"],"prefix":"10.1002","volume":"35","author":[{"given":"Dmitry\u2004V.","family":"Kuprash","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexei V.","family":"Tumanov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry\u2004J.","family":"Liepinsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekaterina\u2004P.","family":"Koroleva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina\u2004S.","family":"Drutskaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei\u2004A.","family":"Kruglov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander\u2004N.","family":"Shakhov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen","family":"Southon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William\u2004J.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lino","family":"Tessarollo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergei\u2004I.","family":"Grivennikov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergei\u2004A.","family":"Nedospasov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,4,22]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1071924"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.4.1397"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.15.8093"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830271020"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90134-C"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/364798a0"},{"key":"e_1_2_7_7_2","doi-asserted-by":"crossref","first-page":"943","DOI":"10.4049\/jimmunol.160.2.943","article-title":"TNF receptor\u2010deficient mice reveal divergent roles for p55 and p75 in several models of inflammation.","volume":"160","author":"Peschon J. 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