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P14 T cells, adoptively transferred into tumor\u2010bearing hosts, induced regression of established 3LL\u2010A9<jats:sub>GP33<\/jats:sub> and MCA102<jats:sub>GP33<\/jats:sub> tumors that express GP33 as a tumor\u2010associated model antigen. Strikingly, the visible effects of P14 T cell attack, such as the destruction of the tumor vasculature and accumulation of granulocytes, were predominantly detected inside the tumor mass. In regressing tumors, P14 T cells were found in the intact rim zone but not in central areas that were infiltrated with granulocytes and lacked CD31<jats:sup>+<\/jats:sup> endothelial cells. The rim of P14 T cell\u2010treated tumors showed an increase in vascular density and decrease in hypoxia compared to untreated tumors. Hypoxic areas of tumors are known to exhibit decreased sensitivity to radiation therapy or chemotherapy. Thus, our data also imply that adoptive transfer of tumor\u2010specific CD8 T cells might synergize with radiation therapy or chemotherapy in the elimination of solid tumors <jats:italic>in vivo<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/eji.200526175","type":"journal-article","created":{"date-parts":[[2005,12,30]],"date-time":"2005-12-30T13:17:42Z","timestamp":1135948662000},"page":"468-477","source":"Crossref","is-referenced-by-count":37,"title":["Solid tumors \u201cmelt\u201d from the inside after successful CD8 T cell attack"],"prefix":"10.1002","volume":"36","author":[{"given":"Ulrike","family":"Blohm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Potthoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert\u2004J.","family":"van\u2004der\u2004Kogel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanspeter","family":"Pircher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,2,2]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.14.1.207"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1006\/smim.1997.0062"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.33.1.29"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.20.100201.131730"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.5.1781"},{"key":"e_1_2_7_6_2","doi-asserted-by":"crossref","first-page":"5309","DOI":"10.4049\/jimmunol.160.11.5309","article-title":"Perforin and IFN\u2010gamma are involved in the antitumor effects of antibody\u2010targeted superantigens.","volume":"160","author":"Rosendahl A.","year":"1998","journal-title":"J. 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