{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:43:42Z","timestamp":1791287022566,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,11,14]],"date-time":"2005-11-14T00:00:00Z","timestamp":1131926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>FTY720 (2\u2010amino\u20102\u2010[2\u2010(4\u2010octylphenyl)ethyl]propane\u20101,3\u2010diol hydrochloride) is an orally available immunomodulatory agent that induces severe peripheral blood lymphopenia. Most studies of these lymphopenic effects have been limited to short\u2010term exposure to FTY720. FTY720 alters the ability of lymphocytes to respond to sphingosine\u20101\u2010phosphate (S1P) through S1P receptors, particularly S1P<jats:sub>1<\/jats:sub>. FTY720 affects different leukocyte populations and their trafficking through major lymphoid organs. We show the dynamics of CD4\u2004T, CD8\u2004T, and B\u2004lymphocyte recirculation in all major lymphoid compartments during 21\u2010day FTY720 treatment of normal C57BL\/6 mice. Following a transient increase in peripheral lymph nodes and Peyer's patches, lymphocyte recirculation reaches a new steady state. Other lymphoid organs show transient changes in lymphocyte composition with various patterns. At 21\u2004days of FTY720 treatment, total body lymphocyte content is reduced by 20% and blood lymphocytes by 80%. Modeling suggests that the new steady state is due to a combination of reduced naive lymphocyte release from the thymus and a transient reduction of lymphocyte egress from lymph nodes. Our data indicate that the commonly held belief that FTY720 blocks lymphocyte egress from lymph nodes cannot fully explain the lymphocyte dynamics observed with prolonged treatment.<\/jats:p>","DOI":"10.1002\/eji.200526218","type":"journal-article","created":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T23:19:56Z","timestamp":1132183196000},"page":"3570-3580","source":"Crossref","is-referenced-by-count":84,"title":["Transient T\u2004cell accumulation in lymph nodes and sustained lymphopenia in mice treated with FTY720"],"prefix":"10.1002","volume":"35","author":[{"given":"Margaret\u2004A.","family":"Morris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David\u2004R.","family":"Gibb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Picard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Brinkmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marty","family":"Straume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Ley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,6]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06534.x"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0548com"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306896200"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02284"},{"key":"e_1_2_7_5_2","doi-asserted-by":"crossref","first-page":"5037","DOI":"10.4049\/jimmunol.160.10.5037","article-title":"FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. 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