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Previous studies in high pathology C3H mice suggested that a strong T cell response was due to the recognition of an immunodominant epitope within the major egg antigen Sm\u2010p40 (Sm\u2010p40<jats:sub>234\u2013246<\/jats:sub>). Using a panel of T cell hybridomas, we have now examined the egg antigen\u2010specific TCR repertoire in two high pathology strains, C3H and CBA. We found that nearly half of the hybridomas responded to the Sm\u2010p40<jats:sub>234\u2013246 <\/jats:sub>epitope and, of these, nearly all expressed V\u03b111.3 associated with V\u03b28. Furthermore, in response to egg antigen stimulation, transcript levels of V\u03b111.3J36 (the most prevalent rearrangement expressed by Sm\u2010p40<jats:sub>234\u2013246<\/jats:sub>\u2010specific hybridomas), increased in high pathology (CBA) but not in low pathology (BALB\/c) strains. Our findings suggest that exacerbated schistosome egg\u2010induced immunopathology can be driven by T cells expressing a highly restricted TCR structure specific for a single parasite epitope.<\/jats:p>","DOI":"10.1002\/eji.200526344","type":"journal-article","created":{"date-parts":[[2005,8,16]],"date-time":"2005-08-16T15:48:07Z","timestamp":1124207287000},"page":"2659-2669","source":"Crossref","is-referenced-by-count":8,"title":["Expansion of CD4 T cells expressing a highly restricted TCR structure specific for a single parasite epitope correlates with high pathology in murine schistosomiasis"],"prefix":"10.1002","volume":"35","author":[{"given":"Eduardo","family":"Finger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter\u2004H.","family":"Brodeur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector\u2004J.","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel\u2004J.","family":"Stadecker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,9,6]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(05)70122-7"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(03)00101-7"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.1.159"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri843"},{"key":"e_1_2_7_5_2","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.4049\/jimmunol.162.5.2884","article-title":"Experimental murine schistosomiasis in the absence of B7 costimulatory molecules: reversal of elicited T cell cytokine profile and partial inhibition of egg granuloma formation.","volume":"162","author":"Hernandez H. 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