{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T15:25:18Z","timestamp":1791127518638,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,4,11]],"date-time":"2006-04-11T00:00:00Z","timestamp":1144713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>B\u20101 and B\u20102 cells are lymphocyte populations that differ in development, surface marker expression, tissue localization, and function. Though mainly found in the spleen, lymph nodes, and circulation of mice, small numbers of B\u20102 cells are found in the peritoneal cavity, a site predominantly populated by B\u20101 cells. Here, we characterized peritoneal B\u20102 cells, and determined their relationship to B\u20101 cells. We found that peritoneal B\u20102 cells appear to be intermediate between splenic B\u20102 and peritoneal B\u20101 cells in terms of surface marker expression of B220, CD80, and CD43, expression of several marker genes, and <jats:italic>in vitro <\/jats:italic>viability and IgM secretion. Adoptive transfer of peritoneal B\u20102 cells into severe combined immunodeficiency mice resulted in the acquisition of a phenotype reminiscent of B\u20101b cells, as shown by up\u2010regulation of Mac\u20101 and CD43, and down\u2010regulation of CD23. Moreover, adoptively transferred peritoneal B\u20102 cells recapitulated B\u20101 cell function by producing natural IgM in recipient mice. These data suggest that peritoneal B\u20102 cells express some characteristics of B\u20101b cells and that this similarity increases with additional time in the peritoneal cavity.<\/jats:p>","DOI":"10.1002\/eji.200535142","type":"journal-article","created":{"date-parts":[[2006,4,11]],"date-time":"2006-04-11T16:27:39Z","timestamp":1144772859000},"page":"1114-1123","source":"Crossref","is-referenced-by-count":61,"title":["Peritoneal B\u20102 cells comprise a distinct B\u20102 cell population with B\u20101b\u2010like characteristics"],"prefix":"10.1002","volume":"36","author":[{"given":"William\u2004D.","family":"Hastings","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph\u2004R.","family":"Tumang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy\u2004W.","family":"Behrens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas\u2004L.","family":"Rothstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,4,25]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.161.6.1554"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/3.6.543"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1301"},{"key":"e_1_2_6_4_2","first-page":"235","article-title":"Treatment of murine CD5\u2013 B cells with anti\u2010Ig, but not LPS, induces surface CD5: two B\u2010cell activation pathways.","volume":"3","author":"Cong Y. 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