{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T13:48:15Z","timestamp":1758980895198},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,6,29]],"date-time":"2006-06-29T00:00:00Z","timestamp":1151539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chimeric mice generated with bone marrow from RelB\u2010deficient (\u2013\/\u2013), RelB\u2010heterozygous (+\/\u2013) and wild\u2010type (+\/+) mice were used to determine how total or partial absence of the transcription factor RelB in haematopoietic cells affects the immune response generated after lymphocytic choriomeningitis virus (LCMV) infection. In RelB<jats:sup>\u2013\/\u2013<\/jats:sup> chimeras, early virus replication was enhanced and LCMV clearance was impaired. Although plasmacytoid dendritic cell numbers were similar, serum interferon (IFN)\u2010\u03b1 levels in RelB<jats:sup>\u2013\/\u2013<\/jats:sup> and RelB<jats:sup>+\/\u2013<\/jats:sup> chimeras were markedly lower than in RelB<jats:sup>+\/+<\/jats:sup> chimeras during early LCMV infection. Further, both RelB<jats:sup>\u2013\/\u2013<\/jats:sup> and RelB<jats:sup>+\/\u2013<\/jats:sup> chimeras mounted a lower\u2010magnitude LCMV\u2010specific CD8<jats:sup>+<\/jats:sup> T cell response than their RelB<jats:sup>+\/+<\/jats:sup> counterparts, although the LCMV\u2010specific CD8<jats:sup>+<\/jats:sup> T cells present were differentiated into functional cytotoxic cells. In LCMV\u2010infected RelB<jats:sup>\u2013\/\u2013<\/jats:sup> mice, induction of cross\u2010priming to an independently injected soluble protein, which depends on the IFN\u2010\u03b1\/\u03b2 made during the viral infection, was also impaired. Notably, provision of exogenous IFN\u2010\u03b1 did not restore the ability of RelB<jats:sup>\u2013\/\u2013<\/jats:sup> mice to cross\u2010prime. In summary, these results show that the RelB\/NF\u2010\u03baB pathway is required for optimal IFN\u2010\u03b1 production after LCMV infection and suggest a crucial role for RelB in IFN\u2010\u03b1\u2010stimulated cross\u2010priming of CD8<jats:sup>+<\/jats:sup> T cell responses.<\/jats:p>","DOI":"10.1002\/eji.200535228","type":"journal-article","created":{"date-parts":[[2006,6,30]],"date-time":"2006-06-30T02:04:04Z","timestamp":1151633044000},"page":"2085-2093","source":"Crossref","is-referenced-by-count":17,"title":["A role for the transcription factor RelB in IFN\u2010\u03b1 production and in IFN\u2010\u03b1\u2010stimulated cross\u2010priming"],"prefix":"10.1002","volume":"36","author":[{"given":"Agne","family":"Le Bon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Montoya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew\u2004J.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clare","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon\u2004A.","family":"Burke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miranda","family":"Ashton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Lo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David\u2004F.","family":"Tough","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Persephone","family":"Borrow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,27]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.16.1.225"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.2.143"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/373531a0"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90416-6"},{"key":"e_1_2_7_5_2","first-page":"375","article-title":"RelB regulation of chemokine expression modulates local inflammation.","volume":"151","author":"Xia Y.","year":"1997","journal-title":"Am. 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