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We show that there are increased numbers of plasmacytoid dendritic cells in CD45<jats:sup>\u2013\/\u2013<\/jats:sup> mice. DC of all mice are capable of responding to lymphocytic choriomeningitis virus (LCMV) infection by up\u2010regulation of MHC and costimulatory molecules. DC of CD45<jats:sup>\u2013\/\u2013<\/jats:sup> mice have an impaired capacity to produce type\u2004I interferons in response to LCMV infection <jats:italic>in vivo<\/jats:italic>. These data indicate that lack of CD45 expression in DC has a profound effect on their function. This is largely restored by CD45RABC or CD45RO transgenes.<\/jats:p>","DOI":"10.1002\/eji.200535304","type":"journal-article","created":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T09:20:10Z","timestamp":1153387210000},"page":"2150-2158","source":"Crossref","is-referenced-by-count":10,"title":["CD45 is required for type\u2004I IFN production by dendritic cells"],"prefix":"10.1002","volume":"36","author":[{"given":"Maria","family":"Montoya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritu","family":"Dawes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delyth","family":"Reid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lian\u2004Ni","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"Piercy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Persephone","family":"Borrow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elma\u2004Z.","family":"Tchilian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter\u2004C.\u2004L.","family":"Beverley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,27]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.21.120601.140946"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/87687"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/35053086"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4652(199703)170:3<235::AID-JCP3>3.0.CO;2-P"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830181102"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(06)00188-6"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.2.471"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-472X(00)00513-0"},{"key":"e_1_2_7_9_2","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.4049\/jimmunol.157.4.1523","article-title":"Enhanced generation of NK cells with intact cytotoxic function in CD45 exon\u20046\u2010deficient mice.","volume":"157","author":"Yamada H.","year":"1996","journal-title":"J. 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