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The chemokine CCL11 is agonist for the chemokine receptor CCR3 and acts in synergy with IL\u20105 to recruit eosinophils to inflammatory sites. The role of CCL11 in gastrointestinal helminth infection has not been previously studied. We challenged wild\u2010type (WT) BALB\/c, CCL11 single knockout (SKO) and CCL11 IL\u20105 double knockout (DKO) mice with either <jats:italic>T. spiralis <\/jats:italic>muscle larvae or <jats:italic>T. muris <\/jats:italic>eggs in order to examine eosinophil recruitment to the small and large intestine during helminth infection. A peripheral eosinophilia was seen in WT and SKO mice during <jats:italic>T. spiralis <\/jats:italic>infection but not with <jats:italic>T. muris. <\/jats:italic>Gastrointestinal eosinophilia was markedly reduced but not ablated in SKO mice \u2010 and negligible in DKO mice \u2010 infected with either nematode. The residual eosinophilia and up\u2010regulation of CCL24 mRNA in the gastrointestinal tract of SKO mice infected with either nematode, together with the presence of an eosinophil\u2010active factor in <jats:italic>T. spiralis <\/jats:italic>and <jats:italic>T. muris <\/jats:italic>products, suggest that CCL11 is the salient but not the sole eosinophil chemoattractant of biological significance during gastrointestinal helminth infection.<\/jats:p>","DOI":"10.1002\/eji.200535492","type":"journal-article","created":{"date-parts":[[2006,6,19]],"date-time":"2006-06-19T11:05:55Z","timestamp":1150715155000},"page":"1753-1763","source":"Crossref","is-referenced-by-count":47,"title":["The role of Th2 cytokines, chemokines and parasite products in eosinophil recruitment to the gastrointestinal mucosa during helminth infection"],"prefix":"10.1002","volume":"36","author":[{"given":"Helen","family":"Dixon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carine","family":"Blanchard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew\u2004L.","family":"deSchoolmeester","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola\u2004C.","family":"Yuill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie\u2004W.","family":"Christie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc\u2004E.","family":"Rothenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn\u2004J.","family":"Else","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,6,30]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.19.8960"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.18.1.217"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119234"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI6560"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.261462598"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.4.785"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.12.6681"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/86365"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.11.5730"},{"issue":"60","key":"e_1_2_7_10_2","article-title":"The life cycle of Trichinella spiralis. 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