{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:28:13Z","timestamp":1791350893558,"version":"4.3.1"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,6,19]],"date-time":"2006-06-19T00:00:00Z","timestamp":1150675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Immunoglobulin\u2004E (IgE) is the key effector element in allergic diseases ranging from innocuous hay fever to life\u2010threatening anaphylactic shock. Compared to other Ig classes, IgE serum levels are very low. In its membrane\u2010bound form (mIgE), IgE behaves as a classical antigen receptor on B\u2004lymphocytes. Expression of mIgE is essential for subsequent recruitment of IgE\u2010secreting cells. We show that in activated, mIgE\u2010bearing B\u2004cells, mRNA for the membrane forms of both murine and human epsilon (\u03f5) heavy chains (HC) are poorly expressed compared to mRNA for the secreted forms. In contrast, in mIgG\u2010bearing B\u2004cells, mRNA for the membrane forms of murine gamma\u20101 (\u03b31) and the corresponding human \u03b34 HC are expressed at a much higher level than mRNA for the respective secreted forms. We show that these findings correlate with the presence of deviant polyadenylation signal hexamers in the 3\u2032\u2004untranslated region (UTR) of both murine and human \u03f5\u2004genes, causing inefficient processing of primary transcripts and thus poor expression of the proteins and poor recruitment of IgE\u2010producing cells in the immune response. Thus, we have identified a genetic steering mechanism in the regulation of IgE synthesis that represents a further means to restrain potentially dangerous, high serum IgE levels.<\/jats:p>","DOI":"10.1002\/eji.200535495","type":"journal-article","created":{"date-parts":[[2006,6,19]],"date-time":"2006-06-19T07:05:32Z","timestamp":1150700732000},"page":"1917-1925","source":"Crossref","is-referenced-by-count":59,"title":["Inefficient processing of mRNA for the membraneform of IgE is a genetic mechanism to limit recruitment of IgE\u2010secreting cells"],"prefix":"10.1002","volume":"36","author":[{"given":"Alexander","family":"Karnowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gertrude","family":"Achatz\u2010Straussberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cordula","family":"Klockenbusch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gernot","family":"Achatz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinus\u2004C.","family":"Lamers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,6,30]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-305X(03)00084-3"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/31927"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(95)80008-5"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.21.120601.141103"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)07302-9"},{"key":"e_1_2_7_6_2","first-page":"122","article-title":"Evidence for the increase in asthma worldwide.","volume":"206","author":"Woolcock A. 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