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Th2\u2010type contact hypersensitivity (CHS) was enhanced and Th1\u2010type CHS was suppressed in these mice. Increased numbers of CC chemokine receptor (CCR)4<jats:sup>+<\/jats:sup> cells and mast cells infiltrated in Tg mice. Levels of IL\u20104 mRNA were higher and those of IFN\u2010\u03b3 mRNA were lower in both acute and chronic CHS. Higher levels of serum IgE were observed after CHS. Numbers of CCR4<jats:sup>+<\/jats:sup> cells among PBMC were increased in Tg mice challenged acutely on the trunk. Chronic irritation with croton oil induced dermatitis and an elevation of serum IgE levels. Tg mice showed enhanced ear swelling after tape stripping. CCL17 was thought to modify the inflammation caused by sensitizing reagents as well as irritant reagents by attracting CCR4<jats:sup>+<\/jats:sup> cells into the lesional skin and creating a Th2\u2010dominant condition. AD\u2010like conditions such as increased number of mast cells and elevated levels of serum IgE were observed. Thus, CCL17 may participate in the pathogenesis of skin diseases such as AD by regulating both allergic and irritant inflammation.<\/jats:p>","DOI":"10.1002\/eji.200535564","type":"journal-article","created":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T09:17:01Z","timestamp":1153387021000},"page":"2116-2127","source":"Crossref","is-referenced-by-count":48,"title":["CCL17 transgenic mice show an enhanced Th2\u2010type response to both allergic and non\u2010allergic 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