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Here, we performed a side\u2010by\u2010side comparison of CD25<jats:sup>+<\/jats:sup> and CD25<jats:sup>\u2013<\/jats:sup> splenic T cells of 100\u2010day tolerant rats. Administration of CD25<jats:sup>\u2013<\/jats:sup> T cells from tolerant rats to sublethally irradiated recipients transferred long\u2010term graft survival. These CD25<jats:sup>\u2013<\/jats:sup> T cells displayed a decreased donor\u2010specific response in the mixed lymphocyte reaction and presented suppressive activity. These CD25<jats:sup>\u2013<\/jats:sup> T cells accumulated IFN\u2010\u03b3, IL\u201010 and Foxp3 transcripts. The <jats:italic>in vitro<\/jats:italic> suppressive activity of CD25<jats:sup>\u2013<\/jats:sup> T cells required both cell contact and soluble factors (IL\u201010 and IFN\u2010\u03b3). The CD25<jats:sup>+<\/jats:sup> T cells from tolerant rats did not show any modification of their regulatory properties. We show that splenic CD25<jats:sup>\u2013<\/jats:sup> T cells of tolerant rats contribute to the maintenance of tolerance following the transplantation. Our data show that regulatory T cells are not restricted to the CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup> T cell subset and provide new insights on the mechanisms of tolerance to allograft following donor cell priming.<\/jats:p>","DOI":"10.1002\/eji.200635879","type":"journal-article","created":{"date-parts":[[2006,12,15]],"date-time":"2006-12-15T10:47:22Z","timestamp":1166179642000},"page":"147-156","source":"Crossref","is-referenced-by-count":11,"title":["Development of CD25<sup>\u2013<\/sup> regulatory T cells following heart transplantation: Evidence for transfer of long\u2010term survival"],"prefix":"10.1002","volume":"37","author":[{"given":"Nicolas","family":"Degauque","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Lair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile","family":"Braudeau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabienne","family":"Haspot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabien","family":"S\u00e9bille","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Dupont","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Merieau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Brouard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Paul","family":"Soulillou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,12,21]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2003.12.007"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199560120-00004"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199704150-00010"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00852877"},{"key":"e_1_2_7_5_2","doi-asserted-by":"crossref","first-page":"463","DOI":"10.4049\/jimmunol.142.2.463","article-title":"Transfusion induces blood donor\u2010specific suppressor cells.","volume":"142","author":"Quigley R. 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