{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T21:03:48Z","timestamp":1784235828720,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The role of CD44 in T cell biology remains incompletely understood. Although studies using anti\u2010CD44 antibodies have implicated this cell adhesion molecule in a variety of important T cell processes, few T cell defects have been reported in CD44\u2010deficient mice. We have assessed the requirement for CD44 in T cell development and mature T cell function by analyzing mice in which CD44<jats:sup>\u2013\/\u2013<\/jats:sup> and WT cells were produced simultaneously. In mixed (CD44<jats:sup>\u2013\/\u2013<\/jats:sup> + CD44<jats:sup>+\/+<\/jats:sup>) bone marrow chimeras, production of CD44<jats:sup>\u2013\/\u2013<\/jats:sup> T cells was shown to be reduced compared to WT cells due to inefficient intrathymic development. In addition, mature CD44<jats:sup>\u2013\/\u2013<\/jats:sup> CD8<jats:sup>+<\/jats:sup> T cells generated a substantially lower response than WT T cells after infection of mice with lymphocytic choriomeningitis virus, with the reduction in response apparent in both lymphoid and non\u2010lymphoid tissues. Overall, these results demonstrate a poor capacity of CD44<jats:sup>\u2013\/\u2013<\/jats:sup> T lineage cells to compete with WT cells at multiple levels, implicating CD44 in normal T cell function.<\/jats:p>","DOI":"10.1002\/eji.200635882","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T20:13:42Z","timestamp":1172780022000},"page":"925-934","source":"Crossref","is-referenced-by-count":31,"title":["A role for CD44 in T cell development and function during direct competition between CD44<sup>+<\/sup> and CD44<sup>\u2013<\/sup> cells"],"prefix":"10.1002","volume":"37","author":[{"given":"Victoria\u2004A.","family":"Graham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda\u2004L.","family":"Marzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David\u2004F.","family":"Tough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,3,28]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(99)00266-X"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60537-4"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.24.12160"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2478(93)90121-H"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.5.1614"},{"key":"e_1_2_7_6_2","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.4049\/jimmunol.150.10.4244","article-title":"A developmental pathway involving four phenotypically and functionally distinct subsets of CD3\u2013CD4\u2013CD8\u2013 triple\u2010negative adult mouse thymocytes defined by CD44 and CD25 expression.","volume":"150","author":"Godfrey D. I.","year":"1993","journal-title":"J. Immunol."},{"key":"e_1_2_7_7_2","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.4049\/jimmunol.138.4.1009","article-title":"Phenotypic identification of memory cytolytic T lymphocytes in a subset of Ly\u20102+ cells.","volume":"138","author":"Budd R. C.","year":"1987","journal-title":"J. Immunol."},{"key":"e_1_2_7_8_2","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.4049\/jimmunol.138.10.3120","article-title":"Distinction of virgin and memory T lymphocytes. Stable acquisition of the Pgp\u20101 glycoprotein concomitant with antigenic stimulation.","volume":"138","author":"Budd R. C.","year":"1987","journal-title":"J. Immunol."},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830170123"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830221036"},{"key":"e_1_2_7_11_2","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.4049\/jimmunol.159.6.2549","article-title":"CD44 activation and associated primary adhesion is inducible via T cell receptor stimulation.","volume":"159","author":"DeGrendele H. C.","year":"1997","journal-title":"J. Immunol."},{"key":"e_1_2_7_12_2","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.4049\/jimmunol.140.5.1401","article-title":"Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA\u20103, CD2, and LFA\u20101) and three other molecules (UCHL1, CDw29, and Pgp\u20101) and have enhanced IFN\u2010\u03b3 production.","volume":"140","author":"Sanders M. E.","year":"1988","journal-title":"J. Immunol."},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(88)90026-3"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.4.1461"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5338.672"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.1.9"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(04)00077-9"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.143.8.2457"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.143.3.798"},{"key":"e_1_2_7_20_2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4049\/jimmunol.144.1.7","article-title":"Antibodies against the CD44 p80, lymphocyte homing receptor molecule augment human peripheral blood T cell activation.","volume":"144","author":"Denning S. M.","year":"1990","journal-title":"J. Immunol."},{"key":"e_1_2_7_21_2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4049\/jimmunol.153.1.21","article-title":"Hyaluronate is costimulatory for human T cell effector functions and binds to CD44 on activated T cells.","volume":"153","author":"Galandrini R.","year":"1994","journal-title":"J. Immunol."},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200010)30:10<2888::AID-IMMU2888>3.0.CO;2-4"},{"key":"e_1_2_7_23_2","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.4049\/jimmunol.147.8.2493","article-title":"Human T cell activation by OKT3 is inhibited by a monoclonal antibody to CD44.","volume":"147","author":"Rothman B. L.","year":"1991","journal-title":"J. Immunol."},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.3109\/08820139909061147"},{"key":"e_1_2_7_25_2","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1182\/blood.V90.6.2217","article-title":"CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity.","volume":"90","author":"Schmits R.","year":"1997","journal-title":"Blood"},{"key":"e_1_2_7_26_2","doi-asserted-by":"crossref","first-page":"4917","DOI":"10.4049\/jimmunol.163.9.4917","article-title":"CD44\u2010deficient mice develop normally with changes in subpopulations and recirculation of lymphocyte subsets.","volume":"163","author":"Protin U.","year":"1999","journal-title":"J. Immunol."},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830270522"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(2001010)31:10<2997::AID-IMMU2997>3.0.CO;2-J"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040394"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200209)32:9<2532::AID-IMMU2532>3.0.CO;2-A"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2277"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.8.4322"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1770237"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.44.28057"},{"key":"e_1_2_7_35_2","doi-asserted-by":"crossref","first-page":"10003","DOI":"10.1016\/S0021-9258(19)50191-0","article-title":"Hyaluronate binding properties of versican.","volume":"267","author":"LeBaron R. G.","year":"1992","journal-title":"J. Biol. Chem."},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1981.tb01672.x"},{"key":"e_1_2_7_37_2","doi-asserted-by":"crossref","first-page":"19536","DOI":"10.1016\/S0021-9258(18)41808-X","article-title":"Cloning and primary structure of neurocan, a developmentally regulated, aggregating chondroitin sulfate proteoglycan of brain.","volume":"267","author":"Rauch U.","year":"1992","journal-title":"J. Biol. Chem."},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.144.4.789"},{"key":"e_1_2_7_39_2","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1083\/jcb.117.6.1343","article-title":"Molecular cloning of a novel hyaluronan receptor that mediates tumor cell motility.","volume":"117","author":"Hardwick C.","year":"1992","journal-title":"J. Cell Biol."},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.8.996"},{"key":"e_1_2_7_41_2","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.4049\/jimmunol.158.3.1417","article-title":"Age\u2010dependent intestinal lymphoproliferative disorder due to stem cell factor receptor deficiency: parameters in small and large intestine.","volume":"158","author":"Laky K.","year":"1997","journal-title":"J. Immunol."},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.9.4504"},{"key":"e_1_2_7_43_2","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.4049\/jimmunol.161.7.3215","article-title":"Cutting edge: Detection of a high frequency of virus\u2010specific CD4+ T cells during acute infection with lymphocytic choriomeningitis virus.","volume":"161","author":"Varga S. M.","year":"1998","journal-title":"J. Immunol."}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.200635882","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.200635882","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T03:19:23Z","timestamp":1697080763000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.200635882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,28]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["10.1002\/eji.200635882"],"URL":"https:\/\/doi.org\/10.1002\/eji.200635882","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,28]]}}}