{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:20:07Z","timestamp":1783426807307,"version":"3.54.6"},"reference-count":57,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,6,19]],"date-time":"2006-06-19T00:00:00Z","timestamp":1150675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>HLA\u2010B*2707 is associated with ankylosing spondylitis in most populations. Like the non\u2010associated allotypes B*2706 and B*2709, it lacks Asp116 and shows preference for peptides with nonpolar C\u2010terminal residues. The relationships between the peptide specificity of B*2707 and those of the disease\u2010associated B*2705 and the non\u2010associated subtypes were analyzed by determining the overlap between the corresponding peptide repertoires, the sequence of shared and differential ligands, and by comparing allospecific T cell epitopes with peptide sharing. The B*2707\u2010bound repertoire was as different from that of B*2705 as from those of B*2706, B*2709, or the two latter subtypes from each other. Differences between B*2707 and B*2705 were based on their C\u2010terminal residue specificity and a subtle modulation at other positions. Differential usage of secondary anchor residues explained the disparity between the B*2707\u2010, B*2706\u2010, and B*2709\u2010bound repertoires. Similar differences in residue usage were found between B*2707 and both B*2704 and B*2706, as expected from the high peptide overlap between the two latter subtypes. T cell cross\u2010reaction paralleled peptide sharing, suggesting that many shared ligands conserve their alloantigenic features on distinct subtypes. Our results indicate that association of HLA\u2010B27 subtypes with ankylosing spondylitis does not correlate with higher peptide sharing among disease\u2010associated subtypes or with obvious peptide motifs.<\/jats:p>","DOI":"10.1002\/eji.200635896","type":"journal-article","created":{"date-parts":[[2006,6,19]],"date-time":"2006-06-19T11:07:27Z","timestamp":1150715247000},"page":"1867-1881","source":"Crossref","is-referenced-by-count":24,"title":["B*2707 differs in peptide specificity from B*2705 and B*2704 as much as from HLA\u2010B27 subtypes not associated to spondyloarthritis"],"prefix":"10.1002","volume":"36","author":[{"given":"Patricia","family":"G\u00f3mez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Montserrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Marcilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Paradela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9\u2004A.\u2004L\u00f3pez","family":"de\u2004Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,6,30]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)91360-3"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197304052881403"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2002.600301.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.2174\/1566524043479293"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(90)90051-A"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M508528200"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10605"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200323678"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.10.5543"},{"key":"e_1_2_7_10_2","doi-asserted-by":"crossref","first-page":"6665","DOI":"10.4049\/jimmunol.163.12.6665","article-title":"Misfolding of HLA\u2010B27 as a result of its B\u2004pocket suggests a novel mechanism for its role in susceptibility to spondyloarthropathies.","volume":"163","author":"Mear J. P.","year":"1999","journal-title":"J. Immunol."},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110336200"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-4310(00)01699-3"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.4.2438"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1995.tb02436.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1997.tb02713.x"},{"key":"e_1_2_7_16_2","first-page":"1111","article-title":"HLA\u2010B27 subtypes positively and negatively associated with spondyloarthropathy.","volume":"24","author":"Nasution A. R.","year":"1997","journal-title":"J. Rheumatol."},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830251133"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10745"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2370.2002.00353.x"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0001-2815.2004.00220.x"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1997.tb02741.x"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830270205"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M200371200"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M204155200"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1997.tb02724.x"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2001.580407.x"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21308"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1155\/2004\/565270"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002510050334"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2004.08.177"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.12.5101"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.5.1059"},{"key":"e_1_2_7_33_2","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.4049\/jimmunol.160.3.1091","article-title":"Class\u2004I\u2010restricted alloreactive cytotoxic T\u2004lymphocytes recognize a complex array of specific MHC\u2010associated peptides.","volume":"160","author":"Wang W.","year":"1998","journal-title":"J. Immunol."},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M505641200"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031690"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80483-5"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21552"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90472-3"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1107\/S1744309105029234"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1107\/S1744309105037966"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M206392200"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M307457200"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M410807200"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2004.12.047"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90010-1"},{"key":"e_1_2_7_46_2","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.4049\/jimmunol.161.10.5481","article-title":"The same natural ligand is involved in allorecognition of multiple HLA\u2010B27 subtypes by a single T cell clone: Role of peptide and the MHC molecule in alloreactivity.","volume":"161","author":"Paradela A.","year":"1998","journal-title":"J. Immunol."},{"key":"e_1_2_7_47_2","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.4049\/jimmunol.163.4.2299","article-title":"High T cell epitope sharing between two HLA\u2010B27 subtypes (B*2705 and B*2709) differentially associated to ankylosing spondylitis.","volume":"163","author":"Garcia\u2010Peydro M.","year":"1999","journal-title":"J. Immunol."},{"key":"e_1_2_7_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1998.tb02941.x"},{"key":"e_1_2_7_49_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI9295"},{"key":"e_1_2_7_50_2","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.4049\/jimmunol.138.6.1657","article-title":"NK susceptibility varies inversely with target cell class\u2004I HLA antigen expression.","volume":"138","author":"Storkus W. J.","year":"1987","journal-title":"J. Immunol."},{"key":"e_1_2_7_51_2","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.4049\/jimmunol.148.6.1941","article-title":"The HLA\u2010A,B \u201cnegative\u201d mutant cell line C1R expresses a novel HLA\u2010B35 allele, which also has a point mutation in the translation initiation codon.","volume":"148","author":"Zemmour J.","year":"1992","journal-title":"J. Immunol."},{"key":"e_1_2_7_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21284"},{"key":"e_1_2_7_53_2","doi-asserted-by":"crossref","first-page":"4038","DOI":"10.4049\/jimmunol.144.10.4038","article-title":"Structure and diversity of HLA\u2010B27\u2010specific T cell epitopes. Analysis with site\u2010directed mutants mimicking HLA\u2010B27 subtype polymorphism.","volume":"144","author":"Calvo V.","year":"1990","journal-title":"J. Immunol."},{"key":"e_1_2_7_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(78)90296-9"},{"key":"e_1_2_7_55_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.1.329"},{"key":"e_1_2_7_56_2","doi-asserted-by":"crossref","first-page":"5557","DOI":"10.4049\/jimmunol.152.11.5557","article-title":"Clonal analysis of alloreactive T cell responses against the closely related B*2705 and B*2703 subtypes. Implications for HLA\u2010B27 association to spondyloarthropathy.","volume":"152","author":"Lopez D.","year":"1994","journal-title":"J. Immunol."},{"key":"e_1_2_7_57_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2002.600115.x"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.200635896","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.200635896","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T10:41:58Z","timestamp":1697625718000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.200635896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6,30]]},"references-count":57,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["10.1002\/eji.200635896"],"URL":"https:\/\/doi.org\/10.1002\/eji.200635896","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6,30]]}}}