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The pro\u2010apoptotic Bcl\u20102 family member, Bcl\u20102 interacting mediator of death (Bim) is critical for eliminating most effector T cells, while expression of CD127 (IL\u20107R\u03b1) has been proposed to mark effector cells destined to become memory cells. Here, we examined the effects of Bim on the death of effector T cells in relationship to CD127 expression and on development of T cell memory following lymphocytic choriomeningitis virus (LCMV) infection. We found that large numbers of CD127<jats:sup>lo<\/jats:sup> LCMV\u2010specific CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> T cells were lost in wild\u2010type mice, but were spared in <jats:italic>Bim<jats:sup>\u2013\/\u2013<\/jats:sup><\/jats:italic> mice. Further, while the numbers of CD127<jats:sup>hi<\/jats:sup> T cells declined only slightly during contraction of the response in wild\u2010type mice, they increased significantly in <jats:italic>Bim<jats:sup>\u2013\/\u2013<\/jats:sup><\/jats:italic> mice due to re\u2010expression of CD127 on CD127<jats:sup>lo<\/jats:sup> T cells that had avoided apoptosis. Functional memory T cells were significantly increased in <jats:italic>Bim<jats:sup>\u2013\/\u2013<\/jats:sup><\/jats:italic> mice; however, they underwent a slow attrition due to decreased proliferative renewal. Taken together, these data suggest that the absence of Bim\u2010mediated death of LCMV\u2010specific CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> T cells <jats:italic>in vivo<\/jats:italic> can increase T cell memory, but other homeostatic mechanisms control the long\u2010term maintenance of memory cells.<\/jats:p>","DOI":"10.1002\/eji.200635897","type":"journal-article","created":{"date-parts":[[2006,6,8]],"date-time":"2006-06-08T10:32:03Z","timestamp":1149762723000},"page":"1694-1706","source":"Crossref","is-referenced-by-count":98,"title":["Bim mediates apoptosis of CD127<sup>lo<\/sup> effector T cells and limits T cell memory"],"prefix":"10.1002","volume":"36","author":[{"given":"Sara","family":"Wojciechowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael\u2004B.","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan\u2004J.","family":"Zajac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David\u2004A.","family":"Hildeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,6,30]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80470-7"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80469-0"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.17.1.221"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(98)80222-7"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3260001"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.1.202-213.2005"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.8.3906-3918.2004"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80668-8"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(94)90067-1"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00322-9"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200002)30:2<683::AID-IMMU683>3.0.CO;2-5"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2336198100"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/7.9.1451"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.2.829-840.2002"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402293101"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(01)00320-3"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.8.3950"},{"key":"e_1_2_7_18_2","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.4049\/jimmunol.162.8.4527","article-title":"Bystander virus infection prolongs activated T cell survival.","volume":"162","author":"Mitchell T.","year":"1999","journal-title":"J. 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