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Tonsilar, but not peripheral blood NK cells enhanced the expansion of IFN\u2010\u03b3\u2010producing CD4<jats:sup>+<\/jats:sup> T cells <jats:italic>via<\/jats:italic> their superior ability to produce IFN\u2010\u03b3. Addition of IFN\u2010\u03b3 increased Th1 polarization while antibody blocking of this cytokine abolished NK cell\u2010dependent Th1 polarization. Our data suggest that NK cells in secondary lymphoid organs assist priming of Th1 cells <jats:italic>via<\/jats:italic> cytokine secretion and this effect should be harnessed during vaccination against viruses and tumors.<\/jats:p>","DOI":"10.1002\/eji.200636290","type":"journal-article","created":{"date-parts":[[2006,8,18]],"date-time":"2006-08-18T09:21:28Z","timestamp":1155892888000},"page":"2394-2400","source":"Crossref","is-referenced-by-count":140,"title":["NK cells of human secondary lymphoid tissues enhance T cell polarization <i>via<\/i> IFN\u2010\u03b3 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