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First, we demonstrate that membrane\u2010bound TNF is sufficient to mediate the inflammatory responses to lipopolysaccharide (LPS). Secondly, using cell type\u2010specific TNF\u2010deficient mice we show that TNF derived from either macrophage\/neutrophil (M\/N) or T lymphocytes have differential effects on LPS\u2010induced respiratory dysfunction (enhanced respiratory pause, Penh) and pulmonary neutrophil recruitment. While Penh, vascular leak, neutrophil recruitment, TNF, and thymus\u2010 and activation\u2010regulated chemokine\/CCL17 (TARC) expression in the lung were reduced in M\/N\u2010deficient mice, T cell\u2010specific TNF\u2010deficient mice displayed augmented Penh, vascular leak, neutrophil influx, increased CD11c<jats:sup>+<\/jats:sup> cells and expression of TNF, TARC and murine CXC chemokines KC\/CXCL1 in the lung. In conclusion, inactivation of TNF in either M\/N or T cells has differential effects on LPS\u2010induced lung disease, suggesting that selective deletion of TNF in T cells may aggravate airway pathology.<\/jats:p>","DOI":"10.1002\/eji.200636371","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T16:42:21Z","timestamp":1171471341000},"page":"768-779","source":"Crossref","is-referenced-by-count":10,"title":["T cell\u2010derived TNF down\u2010regulates acute airway response to endotoxin"],"prefix":"10.1002","volume":"37","author":[{"given":"Dieudonn\u00e9e","family":"Togbe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergei\u2004I.","family":"Grivennikov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Noulin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Couillin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Maillet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muazzam","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marielle","family":"Maret","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizette","family":"Fick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergei\u2004A.","family":"Nedospasov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie\u2004F.\u2004J.","family":"Quesniaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Schnyder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Schnyder\u2010Candrian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,2,23]]},"reference":[{"key":"e_1_2_7_1_2","first-page":"913","article-title":"Endotoxin and lung injury.","volume":"133","author":"Brigham K. 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