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CXCR5<jats:sup>+<\/jats:sup> CD8 T cells were found in tonsil B cell follicles, and isolated cells migrated towards CXCL13 <jats:italic>in vitro<\/jats:italic>. They expressed CD27, CD28, CD45RO, CD69, and were CD7<jats:sup>low<\/jats:sup>, and produced IFN\u2010\u03b3 and granzyme\u2004A but lacked perforin, a functional profile suggesting that these cells are early effector memory cells in the context of contemporary T cell differentiation models. Receptors important in the interaction with B cells, including CD70, OX40 and ICOS, were induced upon activation, and CXCR5<jats:sup>+<\/jats:sup> CD8 T cells could to some extent support survival and IgG production in tonsil B cells. Furthermore, CXCR5<jats:sup>+<\/jats:sup> CD8 T cells expressed CCR5 but no CCR7, suggesting a migration pattern distinct from that of follicular CD4 T cells. The finding that a subset of early effector memory CD8 T cells use CXCR5 to locate to B cell follicles indicates that MHC class\u2004I\u2010restricted CD8 T cells are part of the follicular T cell population.<\/jats:p>","DOI":"10.1002\/eji.200636746","type":"journal-article","created":{"date-parts":[[2007,11,14]],"date-time":"2007-11-14T12:23:19Z","timestamp":1195042999000},"page":"3352-3362","source":"Crossref","is-referenced-by-count":151,"title":["CXCR5<sup>+<\/sup> CCR7<sup>\u2013<\/sup> CD8 T cells are early effector memory cells that infiltrate tonsil B cell 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