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BMP\u20106 rapidly induced phosphorylation of Smad1\/5\/8, p38 and ERK1\/2, followed by a potent up\u2010regulation of ID1, ID2 and ID3. ID1 and ID3 were also induced at the protein level. Genome\u2010wide expression profiling of cells treated with BMP\u20106 compared to medium confirmed that ID1\u2013ID3 were target genes of BMP\u20106 together with Noggin and Smad6. Furthermore, several genes involved in transcriptional regulation were also identified, including NFKBIA, HEY1, DLX2, KLF10 and early growth response\u20041. Stimulation with BMP\u20106 exerted an antiproliferative effect that was counteracted by inhibitor of DNA binding (Id)1 siRNA, indicating that Id1 is an important downstream mediator in Jurkat TAg cells. A subset of CD4<jats:sup>+<\/jats:sup> T cells were found to express the BMP receptors Alk\u20102 and Alk\u20103 (type\u2004I), in addition to BMPRII (type\u2004II). BMP\u20106 also induced phosphorylation of Smad1\/5\/8, followed by transcriptional increase in ID1\u2013ID3 mRNA expression. However, we did not observe significant changes in Id protein expression in CD4<jats:sup>+<\/jats:sup> T cells. Altogether, the data indicate a role for BMP\u20106 in human T\u2004lineage cells.<\/jats:p>","DOI":"10.1002\/eji.200636759","type":"journal-article","created":{"date-parts":[[2007,9,26]],"date-time":"2007-09-26T13:46:59Z","timestamp":1190814419000},"page":"2937-2948","source":"Crossref","is-referenced-by-count":39,"title":["Inhibitory effects and target genes of bone morphogenetic protein\u20046 in Jurkat TAg cells"],"prefix":"10.1002","volume":"37","author":[{"given":"Einar\u2004A.","family":"Sivertsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanutte","family":"Huse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marit\u2004E.","family":"Hystad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Kersten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erlend\u2004B.","family":"Smeland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"June\u2004H.","family":"Myklebust","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,9,26]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3201241"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.2741\/1090"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02006"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.71.5.731"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.10.4241-4254.2004"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209110"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00847-X"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000033830.36431.46"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/35105060"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1260"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205091"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri704"},{"key":"e_1_2_7_13_2","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.4049\/jimmunol.154.4.1634","article-title":"TGF\u2010beta\u20041 and cyclic AMP promote apoptosis in resting human B\u2004lymphocytes.","volume":"154","author":"Lomo J.","year":"1995","journal-title":"J. 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