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Donor IEL homed to the small intestinal epithelium, where they expanded in an IL\u201015\u2010dependent manner and expressed CD69, CD44 and CD103; proliferation did not occur in the spleen, the main other site of IEL detection early after transfer. By 12\u2004days after transfer, a small proportion of intestinal IEL had up\u2010regulated the trafficking molecule CD62L. Four weeks after transfer, donor IEL with a CD69<jats:sup>\u2013<\/jats:sup>CD44<jats:sup>hi<\/jats:sup>CD103<jats:sup>\u2013<\/jats:sup> phenotype similar to memory T cells were present in spleen and other extra\u2010intestinal sites. Treatment of mice with blocking antibody to CD62L reduced appearance of cells in mesenteric lymph nodes; treatment with FTY720, a sphingosine 1\u2010phosphate receptor agonist that blocks egress of T cells from lymph nodes, reduced appearance of cells in spleen. The distribution of TCR\u2004\u03b1\u03b2 and \u03b3\u03b4\u2004IEL varied between organs, \u03b1\u03b2\u2004IEL being predominant. IEL proliferation and emigration under lymphopenic conditions suggests similar IEL turnover, albeit at a lower level, under physiological conditions.<\/jats:p>","DOI":"10.1002\/eji.200636761","type":"journal-article","created":{"date-parts":[[2007,6,27]],"date-time":"2007-06-27T10:48:36Z","timestamp":1182941316000},"page":"2226-2233","source":"Crossref","is-referenced-by-count":10,"title":["Homeostatic proliferation of intestinal intraepithelial lymphocytes precedes their migration to extra\u2010intestinal sites"],"prefix":"10.1002","volume":"37","author":[{"given":"Sanda","family":"Stankovic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifan","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard\u2004C.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,7,26]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1101-997"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00192-3"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(00)00132-0"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041044"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.9.4717"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70316-6"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830270903"},{"key":"e_1_2_7_8_2","doi-asserted-by":"crossref","first-page":"707","DOI":"10.4049\/jimmunol.161.2.707","article-title":"The role of IL\u20107 in thymic and extrathymic development of TCR gamma delta cells.","volume":"161","author":"Laky K.","year":"1998","journal-title":"J. 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