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Using antibody\u2010opsonized liposomes as Ag carriers, we show that mature DC purified from skin explants are able to efficiently capture liposomes, process Ag encapsulated within them and activate Ag\u2010specific CD4<jats:sup>+<\/jats:sup> T cells. Explant DC from mice with Langerhans cells (LC) expressing the primate diphtheria toxin receptor that were exposed to diphtheria toxin <jats:italic>in vivo<\/jats:italic> presented Ag as well as explant DC from wild\u2010type mice, indicating that LC are not required and dermal DC are probably responsible for this presentation. We further show that all DC subtypes from LN that capture opsonized Ag are capable of cross\u2010presenting it to CD8<jats:sup>+<\/jats:sup> T cells. Induction of additional maturation <jats:italic>in vivo<\/jats:italic> by LPS or treatment with double\u2010stranded RNA did not alter the Ag presentation capacity of the skin or LN DC subtypes. These results suggest that mature DC present in skin\u2010draining LN may play an important role in the induction of primary and\/or secondary immune responses against Ag delivered to the LN that they take up by receptor\u2010mediated endocytosis.<\/jats:p>","DOI":"10.1002\/eji.200636793","type":"journal-article","created":{"date-parts":[[2007,4,3]],"date-time":"2007-04-03T13:25:01Z","timestamp":1175606701000},"page":"1184-1193","source":"Crossref","is-referenced-by-count":17,"title":["Mature DC from skin and skin\u2010draining LN retain the ability to acquire and efficiently present targeted antigen"],"prefix":"10.1002","volume":"37","author":[{"given":"Sandrine","family":"Henri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Siret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Machy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Kissenpfennig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Malissen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Leserman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,19]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.2.741"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1340"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-02-0513"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1845"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2729"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.12.7178"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1300"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.2.509"},{"key":"e_1_2_7_9_2","doi-asserted-by":"crossref","first-page":"6059","DOI":"10.4049\/jimmunol.161.11.6059","article-title":"Efficient presentation of multivalent antigens targeted to various cell surface molecules of dendritic cells and surface immunoglobulin of antigen\u2010specific B cells.","volume":"161","author":"Serre K.","year":"1998","journal-title":"J. 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