{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:51:22Z","timestamp":1790981482956,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,6,19]],"date-time":"2007-06-19T00:00:00Z","timestamp":1182211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Autoimmune diseases may develop because of defective maturation, activation, differentiation and function of regulatory T cells. Previous studies have shown that exposure to donor antigen activates peripheral TCR\u03b1\u03b2\n                    <jats:sup>+<\/jats:sup>\n                    CD3\n                    <jats:sup>+<\/jats:sup>\n                    CD4\n                    <jats:sup>\u2013<\/jats:sup>\n                    CD8\n                    <jats:sup>\u2013<\/jats:sup>\n                    NK1.1\n                    <jats:sup>\u2013<\/jats:sup>\n                    , double\u2010negative (DN) T cells, which specifically suppress anti\u2010donor T cells and enhance survival of skin and heart grafts from allogeneic and xenogeneic donors. However, the role of DN T cells in preventing T cell\u2010mediated autoimmune disease is unknown. Here, we analyzed the ability of DN T cells to recognize peptides expressed on self MHC and to suppress peptide\u2010reactive CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells, using the P14 mouse model that expresses a transgenic TCR specific for gp33 peptide presented on self MHC class\u2004I\u2010D\n                    <jats:sup>b<\/jats:sup>\n                    . We found that injection of gp33 peptide resulted in increased DN and decreased CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell numbers in the lymph nodes when compared to untreated mice. Injection of gp33, but not TCR\u2010non\u2010specific AV peptide, increased expression of T cell activation markers on DN T cells. Moreover, gp33\u2010activated DN T cells suppressed proliferation of syngeneic CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells\n                    <jats:italic>via<\/jats:italic>\n                    killing activated CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells in an antigen\u2010specific fashion\n                    <jats:italic>in vitro<\/jats:italic>\n                    . Furthermore, transferring gp33\u2010activated DN T cells inhibited the development of autoimmune diabetes, suggesting that DN T cells may provide a novel therapy for T cell\u2010mediated autoimmune diseases.\n                  <\/jats:p>","DOI":"10.1002\/eji.200636991","type":"journal-article","created":{"date-parts":[[2007,6,19]],"date-time":"2007-06-19T10:17:18Z","timestamp":1182248238000},"page":"2234-2241","source":"Crossref","is-referenced-by-count":56,"title":["Peptide\u2010activated double\u2010negative T cells can prevent autoimmune type\u20101 diabetes development"],"prefix":"10.1002","volume":"37","author":[{"given":"Megan\u2004S.","family":"Ford","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Vanama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisha\u2004R.","family":"Elford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia\u2004L.","family":"Asa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela\u2004S.","family":"Ohashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,7,26]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2006.00421.x"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/08830180500379671"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/08830180500371116"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115643"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02942.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2005.00250.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.11.7135"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2005.09.002"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2005.00247.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2005.04.005"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra055446"},{"key":"e_1_2_7_12_2","first-page":"11","article-title":"Specific control of immunity by regulatory CD8 T cells.","volume":"2","author":"Tang X. 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