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The <jats:italic>in vivo<\/jats:italic> analysis of IL\u20102 function in regulating specific T cell responses has been hampered by the fact that mice deficient in IL\u20102 or its receptors develop lymphoproliferative diseases and\/or autoimmunity. Here we generated chimeric mice harboring both IL\u20102R\u2010competent and IL\u20102R\u2010deficient T cells and assessed CD8<jats:sup>+<\/jats:sup> T cell induction, function and maintenance after acute or persistent viral infections. Induction and maintenance of CD8<jats:sup>+<\/jats:sup> T cells were relatively independent of IL\u20102R signaling during acute\/resolved viral infection. In marked contrast, IL\u20102 was crucial for secondary expansion of memory CD8<jats:sup>+<\/jats:sup> T cells and for the maintenance of virus\u2010specific CD8<jats:sup>+<\/jats:sup> T cells during persistent viral infections. Thus, depending on the chronicity of antigen exposure, IL\u20102R signaling is either essential or largely dispensable for induction and maintenance of virus\u2010specific CD8<jats:sup>+<\/jats:sup> T cell responses.<\/jats:p>","DOI":"10.1002\/eji.200637023","type":"journal-article","created":{"date-parts":[[2007,5,11]],"date-time":"2007-05-11T10:35:18Z","timestamp":1178879718000},"page":"1502-1512","source":"Crossref","is-referenced-by-count":168,"title":["Differential role of IL\u20102R signaling for CD8<sup>+<\/sup> T cell responses in acute and chronic viral infections"],"prefix":"10.1002","volume":"37","author":[{"given":"Martin\u2004F.","family":"Bachmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Wolint","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senta","family":"Walton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Oxenius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,5,24]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3131876"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.11.040193.001333"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8235625"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.69.8.4842-4846.1995"},{"key":"e_1_2_7_5_2","doi-asserted-by":"crossref","first-page":"5690","DOI":"10.4049\/jimmunol.155.12.5690","article-title":"Endogenous IL\u20102 contributes to T cell expansion and IFN\u2010gamma production during lymphocytic choriomeningitis virus infection.","volume":"155","author":"Cousens L. 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