{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:08:30Z","timestamp":1781323710332,"version":"3.54.1"},"reference-count":65,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,4,25]],"date-time":"2007-04-25T00:00:00Z","timestamp":1177459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Erythropoietin (Epo) is the main erythropoietic hormone. Recombinant human Epo (rHuEpo) is thus used in clinical practice for the treatment of anemia. Accumulating data reveals that Epo exerts pleiotropic activities. We have previously shown an anti\u2010neoplastic activity of Epo in murine multiple myeloma (MM) models, and in MM patients. Our findings that this anti\u2010neoplastic effect operates <jats:italic>via<\/jats:italic> CD8<jats:sup>+<\/jats:sup> T lymphocytes led us to hypothesize that Epo possesses a wider range of immunomodulatory functions. Here we demonstrate the effect of Epo on B lymphocyte responses, focusing on three experimental models: (i) tumor\u2010bearing mice, (5T2 MM mouse); (ii) antigen\u2010injected healthy mice; and (iii) antigen\u2010injected transgenic mice (tg6), overexpressing human Epo. In the MM model, despite bone marrow dysfunction, Epo\u2010treated mice retained higher levels of endogenous polyclonal immunoglobulins, compared to their untreated controls. In both Epo\u2010treated wild type and tg6 mice, Epo effect was manifested in the higher levels of splenocyte proliferative response induced <jats:italic>in vitro <\/jats:italic>by lipopolysaccharide. Furthermore, these mice had increased <jats:italic>in vivo<\/jats:italic> production of anti\u2010dinitrophenyl (DNP) antibodies following immunization with DNP\u2010keyhole limpet hemocyanin. Epo\u2010treated mice showed an enhanced immune response also to the clinically relevant hepatitis B surface antigen. These findings suggest a potential novel use of rHuEpo as an immunomodulator.<\/jats:p><jats:p>See accompanying commentary: http:\/\/dx.doi.org\/10.1002\/eji.200737401<\/jats:p>","DOI":"10.1002\/eji.200637025","type":"journal-article","created":{"date-parts":[[2007,4,25]],"date-time":"2007-04-25T16:47:33Z","timestamp":1177519653000},"page":"1584-1593","source":"Crossref","is-referenced-by-count":50,"title":["Erythropoietin enhances immune responses in mice"],"prefix":"10.1002","volume":"37","author":[{"given":"Odelia","family":"Katz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidor","family":"Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilach","family":"Lifshitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Prutchi\u2010Sagiv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Gassmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Mittelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drorit","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,5,24]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200464030-00006"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-8997-0_22"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/62.3.228"},{"key":"e_1_2_7_4_2","first-page":"10","article-title":"Expression of specific high\u2010affinity binding sites for erythropoietin on rat and mouse megakaryocytes.","volume":"17","author":"Fraser J. 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