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These cells rapidly secrete IFN\u2010\u03b3 upon stimulation with IL\u201012\/IL\u201018 and are involved in innate responses to infection with <jats:italic>Listeria monocytogenes<\/jats:italic>. The signals regulating these cells are unclear. The Tec kinase Itk regulates T cell activation and we report here that a majority of the CD8<jats:sup>+<\/jats:sup> T cells in Itk null mice have a phenotype of CD44<jats:sup>hi<\/jats:sup> similar to memory\u2010like innate T cells. These cells are observed in mice carrying an Itk mutant lacking the kinase domain, indicating that active Tec kinase signaling suppresses their presence. These cells carry preformed message for and are able to rapidly produce IFN\u2010\u03b3 upon stimulation <jats:italic>in vitro<\/jats:italic> with IL\u201012\/IL\u201018, and endow Itk null mice the ability to effectively respond to infection with <jats:italic>L. monocytogenes<\/jats:italic> or exposure to lipopolysaccharides by secretion of IFN\u2010\u03b3. Transfer of these cells rescues the ability of IFN\u2010\u03b3 null mice to reduce bacterial burden following <jats:italic>L. monocytogenes<\/jats:italic> infection, indicating that these cells are functional CD8<jats:sup>+<\/jats:sup>CD44<jats:sup>hi<\/jats:sup> T cells previously detected <jats:italic>in vivo<\/jats:italic>. These results indicate that active signals from Tec kinases regulate the development of memory\u2010like CD8<jats:sup>+<\/jats:sup> T cells with innate function.<\/jats:p>","DOI":"10.1002\/eji.200737311","type":"journal-article","created":{"date-parts":[[2007,8,27]],"date-time":"2007-08-27T16:18:40Z","timestamp":1188231520000},"page":"2892-2899","source":"Crossref","is-referenced-by-count":70,"title":["Memory phenotype CD8<sup>+<\/sup> T cells with innate function selectively develop in the absence of active Itk"],"prefix":"10.1002","volume":"37","author":[{"given":"Jianfang","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisebita","family":"Sahu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avery","family":"August","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,9,26]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.20.9347"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5414.638"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90065-9"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.10.1721"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-6-19"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80115-6"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni734"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.7.3895"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.10.5056"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.12.1330"},{"key":"e_1_2_7_11_2","doi-asserted-by":"crossref","first-page":"7253","DOI":"10.1128\/jvi.71.10.7253-7257.1997","article-title":"Antiviral immune responses in Itk\u2010deficient mice.","volume":"71","author":"Bachmann M.","year":"1997","journal-title":"J. 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