{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:54:03Z","timestamp":1791215643560,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2007,10,12]],"date-time":"2007-10-12T00:00:00Z","timestamp":1192147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>IL\u20107 and IL\u201015 are important cytokines for CD8 memory T cells. However, the extent that IL\u20107 is essential for CD8 T cell memory remains unclear because blocking IL\u20107 <jats:italic>in vivo<\/jats:italic> results in near complete inhibition of T cell development with the few mature T cells exhibiting functional abnormalities. To bypass this complication, CD8 memory development was examined utilizing a mouse model where transgenic IL\u20107R\u03b1 was selectively expressed in the thymus of IL\u20107R\u03b1<jats:sup>\u2013\/\u2013<\/jats:sup> mice. T cell development was corrected but the resulting peripheral T cells were essentially IL\u20107 non\u2010responsive. Activation of IL\u20107R\u2010defective OT\u2010I CD8<jats:sup>+<\/jats:sup> T cells with OVA<jats:sub>257\u2013264<\/jats:sub> and IL\u20102 readily yielded CTL. Upon further culture with IL\u201015, these CTL expressed phenotypic and functional properties of central memory\u2010like cells. Thus, IL\u20107R\u2010defective CD8<jats:sup>+<\/jats:sup> T cells do not exhibit intrinsic defects in effector or memory development. When IL\u20107R\u2010defective OT\u2010I CTL were adoptively transferred into normal or IL\u201015<jats:sup>\u2013\/\u2013<\/jats:sup> recipient mice in a non\u2010inflammatory setting, they converted into memory\u2010like cells, but did not persist, which was even more striking in IL\u201015<jats:sup>\u2013\/\u2013<\/jats:sup> recipients. This poor persistence was rescued after expression of transgenic Bcl\u20102 in IL\u20107R\u2010defective OT\u2010I T cells. Collectively, these data indicate that IL\u20107 is non\u2010redundantly required for the survival of CD8 memory T cells.<\/jats:p>","DOI":"10.1002\/eji.200737585","type":"journal-article","created":{"date-parts":[[2007,10,12]],"date-time":"2007-10-12T13:18:12Z","timestamp":1192195092000},"page":"3078-3088","source":"Crossref","is-referenced-by-count":46,"title":["Non\u2010redundant role for IL\u20107R signaling for the survival of CD8<sup>+<\/sup> memory T cells"],"prefix":"10.1002","volume":"37","author":[{"given":"Roberto","family":"Carrio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cleo\u2004E.","family":"Rolle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas\u2004R.","family":"Malek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,10,24]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri778"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni804"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/87720"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/87730"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.12.6833"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.24.021605.090727"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1052"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.052676899"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04790"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0737048100"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2006.00401.x"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-0757-4_22"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020033"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(02)00211-0"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(02)00029-1"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.10.4827"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020369"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020067"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020066"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/80868"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1009"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.7.4247"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.7.4400"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.7.4458"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.5.1955"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.14.7172"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.181.4.1519"},{"key":"e_1_2_8_28_2","doi-asserted-by":"crossref","first-page":"5315","DOI":"10.4049\/jimmunol.157.12.5315","article-title":"Impaired survival and proliferation in IL\u20107 receptor\u2010deficient peripheral T cells.","volume":"157","author":"Maraskovsky E.","year":"1996","journal-title":"J. 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