{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:41:39Z","timestamp":1786977699191,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,2,12]],"date-time":"2008-02-12T00:00:00Z","timestamp":1202774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Lipids are key regulators of immune responses. In this study we investigated the direct impact of oxidized phospholipids (ox\u2010PL) on T cell activation and function. We could demonstrate that ox\u2010PL strongly inhibit proliferation of purified human T cells induced with anti\u2010CD3\/CD28 or anti\u2010CD3\/CD63 mAb, whereas proliferation of naive T cells from human cord blood was not affected by ox\u2010PL. Unoxidized phospholipids showed no such effect. Inhibition of T cell proliferation by ox\u2010PL was not due to cell death. Moreover, T cell proliferation triggered by PMA\/ionomycin activation was not diminished by ox\u2010PL. T cells activated in the presence of ox\u2010PL produced and released low amounts of IFN\u2010\u03b3 and IL\u20102, whereas IL\u20104 was only slightly diminished. Ox\u2010PL prevented the expression of\n                    <jats:italic>de novo<\/jats:italic>\n                    synthesized activation markers (CD25, MHC class\u2004II) but not expression of CD63 or CD69. We further observed that T cells stimulated in the presence of ox\u2010PL are poorly cytotoxic T cells. Most importantly, T cells activated in the presence of ox\u2010PL failed to proliferate in response to restimulation. This hypo\u2010proliferative state was accompanied with an up\u2010regulation of early growth response gene\u20043 and Casitas B\u2010lineage lymphoma protein\u2004B. Taken together, our results demonstrate that ox\u2010PL are potent and specific regulators of T cell activation and function.\n                  <\/jats:p>","DOI":"10.1002\/eji.200737619","type":"journal-article","created":{"date-parts":[[2008,2,12]],"date-time":"2008-02-12T07:20:23Z","timestamp":1202800823000},"page":"778-787","source":"Crossref","is-referenced-by-count":30,"title":["Oxidized phospholipids induce anergy in human peripheral blood T cells"],"prefix":"10.1002","volume":"38","author":[{"given":"Maria","family":"Seyerl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Bl\u00fcml","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Kirchberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valery N.","family":"Bochkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Oskolkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto","family":"Majdic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"St\u00f6ckl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,2,19]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-003-0467-2"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-200310000-00002"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01023"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.2.993"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.1.501"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.10.6000"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.21.13597"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2131"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-8411(03)00044-1"},{"key":"e_1_2_8_10_2","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.4049\/jimmunol.160.7.3188","article-title":"Inhibitory and stimulatory effects of IL\u201010 on human CD8+ T cells.","volume":"160","author":"Groux H.","year":"1998","journal-title":"J. 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