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Using IgM and IgA ligands and newly generated Fc\u03b1\/\u03bcR specific monoclonal antibodies we have defined biochemical features and cellular distribution of the human Fc\u03b1\/\u03bcR. Both recombinant and native forms of human Fc\u03b1\/\u03bcR are expressed on the cell surface as remarkably stable homodimeric transmembrane glycoproteins that can bind specifically polymeric IgM or IgA. The only human B cells to express Fc\u03b1\/\u03bcR, albeit at very low levels, are found in the pre\u2010germinal center subpopulation defined by the IgD<jats:sup>+<\/jats:sup>\/CD38<jats:sup>+<\/jats:sup> phenotype. Hence the expression pattern differs from that of the mouse wherein Fc\u03b1\/\u03bcR is expressed by both circulating and resident B cell populations. Significantly, the predominant cell type expressing the Fc\u03b1\/\u03bcR in humans is the follicular dendritic cell of germinal centers. The Fc\u03b1\/\u03bcR may thus function in antigen presentation and B cell selection in the germinal center response.<\/jats:p>","DOI":"10.1002\/eji.200737655","type":"journal-article","created":{"date-parts":[[2007,11,14]],"date-time":"2007-11-14T12:23:58Z","timestamp":1195043038000},"page":"3540-3550","source":"Crossref","is-referenced-by-count":62,"title":["Unusual biochemical features and follicular dendritic cell expression of human Fc\u03b1\/\u03bc receptor"],"prefix":"10.1002","volume":"37","author":[{"given":"Kaoru","family":"Kikuno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Won","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Tahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuko","family":"Torii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Homare\u2004M.","family":"Kubagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang\u2004Jey","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Baudino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Nishizaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Shibuya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Kubagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,11,29]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.15.1.203"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.17.1.931"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.19.1.275"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.21.120601.141011"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.05.010"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.146.1.184"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1981.tb01046.x"},{"key":"e_1_2_8_8_2","first-page":"1","article-title":"Characteristics and function of Fc receptors on human lymphocytes.","volume":"47","author":"Lydyard P. 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