{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:54:03Z","timestamp":1791215643607,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,5,28]],"date-time":"2008-05-28T00:00:00Z","timestamp":1211932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>CD4<jats:sup>+<\/jats:sup> T cell help during the priming of CD8<jats:sup>+<\/jats:sup> T lymphocytes imprints the capacity for optimal secondary expansion upon re\u2010encounter with antigen. Helped memory CD8<jats:sup>+<\/jats:sup> T cells rapidly expand in response to a secondary antigen exposure, even in the absence of T cell help and, are most efficient in protection against a re\u2010infection. In contrast, helpless memory CTL can mediate effector function, but secondary expansion is reduced. How CD4<jats:sup>+<\/jats:sup> T cells instruct CD8<jats:sup>+<\/jats:sup> memory T cells during priming to undergo efficient secondary expansion has not been resolved in detail. Here, we show that memory CTL after infection with lymphocytic choriomeningitis virus are CD27<jats:sup>high<\/jats:sup> whereas memory CTL primed in the absence of CD4<jats:sup>+<\/jats:sup> T cell have a reduced expression of CD27. Helpless memory CTL produced low amounts of IL\u20102 and did not efficiently expand after restimulation with peptide <jats:italic>in vitro<\/jats:italic>. Blocking experiments with monoclonal antibodies and the use of CD27<jats:sup>\u2013\/\u2013<\/jats:sup> memory CTL revealed that CD27 ligation during restimulation increased autocrine IL\u20102 production and secondary expansion. Therefore, regulating CD27 expression on memory CTL is a novel mechanism how CD4<jats:sup>+<\/jats:sup> T cells control CTL memory.<\/jats:p>","DOI":"10.1002\/eji.200737824","type":"journal-article","created":{"date-parts":[[2008,5,28]],"date-time":"2008-05-28T10:32:15Z","timestamp":1211970735000},"page":"1847-1856","source":"Crossref","is-referenced-by-count":32,"title":["CD4<sup>+<\/sup> T cell help improves CD8<sup>+<\/sup> T cell memory by retained CD27 expression"],"prefix":"10.1002","volume":"38","author":[{"given":"Matthias\u2004S.","family":"Matter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Claus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian\u2004F.","family":"Ochsenbein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,6,25]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/87720"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/87730"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni804"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1083317"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1082305"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01441"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072615"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03337"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/31002"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/30989"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/30996"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.11.6542"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0202-166"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04790"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070543"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200637023"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/44385"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070322"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0402-379"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.9.1407"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni889"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1148"},{"key":"e_1_2_8_23_2","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.4049\/jimmunol.154.6.2612","article-title":"Engagement of CD27 with its ligand CD70 provides a second signal for T cell activation.","volume":"154","author":"Hintzen R. 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