{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:31:44Z","timestamp":1791311504757,"version":"4.3.1"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,2,5]],"date-time":"2008-02-05T00:00:00Z","timestamp":1202169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>IL\u20101 is an important mediator of inflammation and a major cause of tissue damage in rheumatoid arthritis (RA). Therapeutic administration of recombinant IL\u20101 receptor antagonist (IL\u20101Ra) is efficacious in reducing clinical symptoms of disease, but suffers from several drawbacks, including the need for frequent administrations of large amounts. Here, we show that immunization of mice with either IL\u20101\u03b1 or IL\u20101\u03b2 chemically cross\u2010linked to virus\u2010like particles (VLP) of the bacteriophage Q\u03b2 elicited a rapid and long\u2010lasting autoantibody response. The induced Ab efficiently neutralized the binding of the respective IL\u20101 molecules to their receptors <jats:italic>in vitro<\/jats:italic> and their pro\u2010inflammatory activities <jats:italic>in vivo<\/jats:italic>. In the collagen\u2010induced arthritis model, both vaccines strongly protected mice from inflammation and degradation of bone and cartilage. Moreover, immunization with either vaccine showed superior efficacy than daily administrations of high amounts of IL\u20101Ra. In the T and B cell\u2010independent collagen Ab transfer model, immunization with the IL\u20101\u03b2 vaccine strongly protected from arthritis, whereas immunization with the IL\u20101\u03b1 vaccine had no effect. Our results suggest that active immunization with IL\u20101\u03b1, and especially IL\u20101\u03b2 conjugated to Q\u03b2 VLP, might become an efficacious and cost\u2010effective new treatment option for RA and other systemic IL\u20101\u2010dependent inflammatory disorders.<\/jats:p>","DOI":"10.1002\/eji.200737989","type":"journal-article","created":{"date-parts":[[2008,2,5]],"date-time":"2008-02-05T14:46:42Z","timestamp":1202222802000},"page":"877-887","source":"Crossref","is-referenced-by-count":83,"title":["Active immunization with IL\u20101 displayed on virus\u2010like particles protects from autoimmune arthritis"],"prefix":"10.1002","volume":"38","author":[{"given":"Gunther","family":"Spohn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Beck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Grest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary\u2004T.","family":"Jennings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin\u2004F.","family":"Bachmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,2,19]]},"reference":[{"issue":"2","key":"e_1_2_7_1_2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/rheumatology\/XXXIV.suppl_2.59","article-title":"Long\u2010term outcomes in rheumatoid arthritis.","volume":"34","author":"Pincus T.","year":"1995","journal-title":"Br. 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