{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:44:35Z","timestamp":1791423875993,"version":"4.3.3"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2008,10,31]],"date-time":"2008-10-31T00:00:00Z","timestamp":1225411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>DC are a highly heterogeneous population that plays a critical role in host defense. We previously demonstrated that virus infection induces BM plasmacytoid DC (pDC) differentiation into CD11b<jats:sup>+<\/jats:sup> conventional DC (cDC) upon <jats:italic>in vitro<\/jats:italic> culture with Fms\u2010like tyrosine kinase 3 ligand (Flt3L). Here we use immunoglobulin D\u2010J rearrangements and pDC adoptive transfer to provide definitive proof supporting BM pDC conversion into CD11b<jats:sup>+<\/jats:sup> cDC during <jats:italic>in vivo<\/jats:italic> viral infection. We show that <jats:italic>in vivo<\/jats:italic> BM pDC conversion into CD11b<jats:sup>+<\/jats:sup> cDC relates to enhanced ability to prime virus\u2010specific T cells. Furthermore, we demonstrate that <jats:italic>in vivo<\/jats:italic> pDC conversion does not rely on viral infection of BM pDC, but instead is mediated by type I IFN signaling. Finally, by exploiting recently identified pDC\u2010specific Ab, we provide further characterizations of the BM pDC fraction that exhibits this broader developmental plasticity. Collectively, these data indicate that BM pDC actively contribute to the CD11b<jats:sup>+<\/jats:sup> cDC pool during <jats:italic>in vivo<\/jats:italic> viral infection and delineates molecular, functional, and phenotypic features of this novel developmental pathway.<\/jats:p>","DOI":"10.1002\/eji.200838282","type":"journal-article","created":{"date-parts":[[2008,10,31]],"date-time":"2008-10-31T10:43:44Z","timestamp":1225449824000},"page":"3388-3394","source":"Crossref","is-referenced-by-count":30,"title":["<i>In vivo<\/i> conversion of BM plasmacytoid DC into CD11b<sup>+<\/sup> conventional DC during virus infection"],"prefix":"10.1002","volume":"38","author":[{"given":"Li\u2010Ying","family":"Liou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda L.","family":"Blasius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan J.","family":"Welch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Colonna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B. 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