{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:00:21Z","timestamp":1791248421518,"version":"4.1.0"},"reference-count":67,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2008,7,15]],"date-time":"2008-07-15T00:00:00Z","timestamp":1216080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Although \u03b3\u03b4\u2004T cells play a role in protecting tissues from pathogen\u2010elicited damage to bacterial, viral and parasitic pathogens, the mechanisms involved in the damage and in the protection have not been clearly elucidated. This has been addressed using a murine model of listeriosis, which in mice lacking \u03b3\u03b4\u2004T cells (TCR\u03b4\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    ) is characterised by severe and extensive immune\u2010mediated hepatic necrosis. We show that these hepatic lesions are caused by\n                    <jats:italic>Listeria<\/jats:italic>\n                    \u2010elicited CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells secreting high levels of TNF\u2010\u03b1 that accumulate in the liver of\n                    <jats:italic>Listeria<\/jats:italic>\n                    \u2010infected TCR\u03b4\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice. Using isolated populations of \u03b3\u03b4\u2004T cells from wild\u2010type and cytokine\u2010deficient strains of mice to reconstitute TCR\u03b4\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice, the TCR variable gene\u20044 (V\u03b34)\n                    <jats:sup>+<\/jats:sup>\n                    subset of \u03b3\u03b4\u2004T cells was shown to protect against liver injury. Hepatoprotection was dependent upon their ability to produce IL\u201010 after TCR\u2010mediated interactions with\n                    <jats:italic>Listeria<\/jats:italic>\n                    \u2010elicited macrophages and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. IL\u201010\u2010producing V\u03b34\n                    <jats:sup>+<\/jats:sup>\n                    T cells also contribute to controlling CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell expansion and to regulating and reducing TNF\u2010\u03b1 secretion by activated CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. This effect on TNF\u2010\u03b1 production was directly attributed to IL\u201010. These findings identify a novel mechanism by which pathogen\u2010elicited CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells are regulated\n                    <jats:italic>via<\/jats:italic>\n                    interactions with, and activation of, IL\u201010\u2010producing hepatoprotective \u03b3\u03b4\u2004T cells.\n                  <\/jats:p>","DOI":"10.1002\/eji.200838354","type":"journal-article","created":{"date-parts":[[2008,7,15]],"date-time":"2008-07-15T03:56:29Z","timestamp":1216094189000},"page":"2274-2283","source":"Crossref","is-referenced-by-count":77,"title":["A subset of IL\u201010\u2010producing \u03b3\u03b4\u2004T cells protect the liver from\n                    <i>Listeria<\/i>\n                    \u2010elicited, CD8\n                    <sup>+<\/sup>\n                    T cell\u2010mediated injury"],"prefix":"10.1002","volume":"38","author":[{"given":"Katherine\u2004A.","family":"Rhodes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth\u2004M.","family":"Andrew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren\u2004J.","family":"Newton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Tramonti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon\u2004R.","family":"Carding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,7,24]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.05.005"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1461"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.12.8191"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23493"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.07.041"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24282"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.04.062"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119308"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.171.4.1141"},{"key":"e_1_2_8_10_2","doi-asserted-by":"crossref","first-page":"5090","DOI":"10.1128\/iai.61.12.5090-5096.1993","article-title":"Neutrophils are involved in acute, nonspecific resistance to Listeria moncytogenes in mice.","volume":"61","author":"Rogers H. W.","year":"1993","journal-title":"Infect. Immun."},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.1.259"},{"key":"e_1_2_8_12_2","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.4049\/jimmunol.152.4.1836","article-title":"Administration of anti\u2010granulocyte mAb RB6\u20108C5 impairs the resistance of mice to Listeria monocytogenes infection.","volume":"152","author":"Czuprynski C. J.","year":"1994","journal-title":"J. Immunol."},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.18.1.275"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0528.2002.017405.x"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90163-9"},{"key":"e_1_2_8_16_2","doi-asserted-by":"crossref","first-page":"5297","DOI":"10.4049\/jimmunol.158.11.5297","article-title":"Impaired macrophage listericidal and cytokine activities are responsible for the rapid death of Listeria monocytogenes\u2010infected IFN\u2010gamma\u2010deficient mice.","volume":"158","author":"Dai W. J.","year":"1997","journal-title":"J. Immunol."},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.3.1871"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.3.1751"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90134-C"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/364798a0"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.4.1397"},{"key":"e_1_2_8_22_2","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.4049\/jimmunol.144.7.2609","article-title":"Cytokine\u2010induced gene expression of a neutrophil chemotactic factor\/IL\u201018 in human hepatocytes.","volume":"144","author":"Thornton A. J.","year":"1990","journal-title":"J. Immunol."},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510230315"},{"key":"e_1_2_8_24_2","doi-asserted-by":"crossref","first-page":"5941","DOI":"10.4049\/jimmunol.158.12.5941","article-title":"Transcriptional activation of vascular cell adhesion molecule\u20101 gene in vivo and its role in the pathophysiology of neutrophil\u2010induced liver injury in murine endotoxin shock.","volume":"158","author":"Essani N. A.","year":"1997","journal-title":"J. Immunol."},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.8.4787-4792.2005"},{"key":"e_1_2_8_26_2","doi-asserted-by":"crossref","first-page":"3480","DOI":"10.4049\/jimmunol.160.7.3480","article-title":"Activation of caspase\u20043 (CPP32)\u2010like proteases is essential for TNF\u2010alpha\u2010induced hepatic parenchymal cell apoptosis and neutrophil\u2010mediated necrosis in a murine endotoxin shock model.","volume":"160","author":"Jaeschke H.","year":"1998","journal-title":"J. Immunol."},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.34615"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.6.2994"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/365053a0"},{"key":"e_1_2_8_30_2","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.4049\/jimmunol.153.7.3101","article-title":"Immune protection and control of inflammatory tissue necrosis by \u03b3\u03b4\u2004T cells.","volume":"153","author":"Fu Y.\u2010X.","year":"1994","journal-title":"J. Immunol."},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1006\/mpat.1996.0095"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.3.1741"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/322836a0"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.12.7213-7223.2001"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(99)80311-0"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2004.tb00469.x"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.11.016"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200635959"},{"key":"e_1_2_8_39_2","doi-asserted-by":"crossref","first-page":"5221","DOI":"10.4049\/jimmunol.160.11.5221","article-title":"Early preferential stimulation of \u03b3\u03b4\u2004T cells by TNF\u03b1.","volume":"160","author":"Lahn M.","year":"1998","journal-title":"J. Immunol."},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2004.12.010"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.02.009"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1098"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60400-9"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.1.507"},{"key":"e_1_2_8_45_2","doi-asserted-by":"crossref","first-page":"663","DOI":"10.4049\/jimmunol.156.2.663","article-title":"IL\u201015 is a novel growth factor for murine \u03b3\u03b4\u2004T cells induced by Salmonella infection.","volume":"156","author":"Nishimura H.","year":"1996","journal-title":"J. Immunol."},{"key":"e_1_2_8_46_2","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.1128\/IAI.66.7.3270-3278.1998","article-title":"Protective roles of \u03b3\u03b4\u2004T cells and interleukin\u201015 in Escherichia coli infection in mice.","volume":"66","author":"Takano M.","year":"1998","journal-title":"Infect. Immun."},{"key":"e_1_2_8_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1267"},{"key":"e_1_2_8_48_2","doi-asserted-by":"crossref","first-page":"568","DOI":"10.4049\/jimmunol.149.2.568","article-title":"Sequential analysis of T cells in the liver during murine listerial infection.","volume":"149","author":"Hiromatsu K.","year":"1992","journal-title":"J. Immunol."},{"key":"e_1_2_8_49_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.175.1.49"},{"key":"e_1_2_8_50_2","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.4049\/jimmunol.154.3.1307","article-title":"Activation of the 55\u2004kDa TNF receptor is necessary and sufficient for TNF\u2010induced liver failure, hepatocyte apoptosis, and nitrite release.","volume":"154","author":"Leist M.","year":"1995","journal-title":"J. Immunol."},{"key":"e_1_2_8_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0171-2985(99)80059-X"},{"key":"e_1_2_8_52_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.3.1786"},{"key":"e_1_2_8_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00000281"},{"key":"e_1_2_8_54_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031051"},{"key":"e_1_2_8_55_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.10.5387"},{"key":"e_1_2_8_56_2","doi-asserted-by":"crossref","first-page":"4473","DOI":"10.4049\/jimmunol.160.9.4473","article-title":"IL\u201010 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required for immune down\u2010modulation of chronic disease.","volume":"160","author":"Wynn T. A.","year":"1998","journal-title":"J. Immunol."},{"key":"e_1_2_8_57_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.10.5375"},{"key":"e_1_2_8_58_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.6.3142"},{"key":"e_1_2_8_59_2","doi-asserted-by":"crossref","first-page":"242","DOI":"10.4049\/jimmunol.163.1.242","article-title":"Depletion of IL\u201010\u2010 and TGF\u2010\u03b2\u2010producing \u03b3\u03b4\u2004T cells by administering a daunomycin\u2010conjugated specific monoclonal antibody in early tumor lesions augments the activity of CTLs and NK cells.","volume":"163","author":"Seo N.","year":"1999","journal-title":"J. Immunol."},{"key":"e_1_2_8_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-8749(03)00066-2"},{"key":"e_1_2_8_61_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.12.8331"},{"key":"e_1_2_8_62_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0500419102"},{"key":"e_1_2_8_63_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.132519299"},{"key":"e_1_2_8_64_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.5.2894"},{"key":"e_1_2_8_65_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.8.4174"},{"key":"e_1_2_8_66_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.6.3147"},{"key":"e_1_2_8_67_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830271020"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.200838354","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.200838354","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T05:12:24Z","timestamp":1697087544000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.200838354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,24]]},"references-count":67,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["10.1002\/eji.200838354"],"URL":"https:\/\/doi.org\/10.1002\/eji.200838354","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,24]]}}}