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In a previous study, antigens secreted by <jats:italic>Sporothrix schenckii<\/jats:italic> induced a specific humoral response in infected animals, mainly against the 70\u2010kDa molecule, indicating a possible participation of antibodies to this antigen in infection control. In the present study, an IgG1 mAb was produced against a 70\u2010kDa glycoprotein of <jats:italic>S. schenckii<\/jats:italic> in order to better understand the effect of passive immunization of mice infected with <jats:italic>S. schenckii<\/jats:italic>. Results showed a significant reduction in the number of CFU in organs of mice when the mAb was injected before and during <jats:italic>S. schenckii<\/jats:italic> infection. Similar results were observed when T\u2010cell\u2010deficient mice were used. Moreover, in a second schedule treatment, the mAb was injected after infection was established, and again we observed a significant reduction in CFU associated with an increase of IFN\u2010\u03b3production. Also, the 70\u2010kDa antigen is shown to be a putative adhesin present on the surface of this fungus. In conclusion, we report for the first time the protective effect of a specific antibody against <jats:italic>S. schenckii.<\/jats:italic><\/jats:p>","DOI":"10.1002\/eji.200838513","type":"journal-article","created":{"date-parts":[[2008,11,7]],"date-time":"2008-11-07T09:30:05Z","timestamp":1226050205000},"page":"3080-3089","source":"Crossref","is-referenced-by-count":82,"title":["Passive immunization with monoclonal antibody against a 70\u2010kDa putative adhesin of <i>Sporothrix schenckii<\/i> induces protection in murine sporotrichosis"],"prefix":"10.1002","volume":"38","author":[{"given":"Rosana C.","family":"Nascimento","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noeli M.","family":"Esp\u00edndola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaela A.","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro A. 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