{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T13:09:15Z","timestamp":1791032955110,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,3,31]],"date-time":"2009-03-31T00:00:00Z","timestamp":1238457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Regulatory CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells are important for the homeostasis of immune cells, and their absence correlates with autoimmune disorders. However, how the immune system regulates Treg homeostasis remains unclear. We found that IFN\u2010\u03b3\u2010deficient\u2010mice had more forkhead box P3 (FOXP3\n                    <jats:sup>+<\/jats:sup>\n                    ) cells than WT mice in all secondary lymphoid organs except the thymus. However, T\u2010bet\u2010 or IL\u20104R\u03b1\u2010deficient mice did not show a similar increase.\n                    <jats:italic>In vitro<\/jats:italic>\n                    differentiation studies showed that conversion of na\u00efve T cells into FOXP3\n                    <jats:sup>+<\/jats:sup>\n                    cells (neo\u2010generated inducible Treg (iTreg)) by TGF\u2010\u03b2 was significantly inhibited by IFN\u2010\u03b3 in a STAT\u20101\u2010dependent manner. Moreover, an\n                    <jats:italic>in vivo<\/jats:italic>\n                    adoptive transfer study showed that inhibition of FOXP3\n                    <jats:sup>+<\/jats:sup>\n                    iTreg generation by IFN\u2010\u03b3 was a T\u2010cell autocrine effect. This inhibitory effect of IFN\u2010\u03b3 on iTreg generation was significantly abrogated after\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetyl\u2010\n                    <jats:sc>L<\/jats:sc>\n                    \u2010cysteine treatment both\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    , indicating that IFN\u2010\u03b3 regulation of iTreg generation is dependent on ROS\u2010mediated apoptosis. Therefore, our results suggest that autocrine IFN\u2010\u03b3 can negatively regulate the neo\u2010generation of FOXP3\n                    <jats:sup>+<\/jats:sup>\n                    iTreg through ROS\u2010mediated apoptosis in the periphery.\n                  <\/jats:p>","DOI":"10.1002\/eji.200838913","type":"journal-article","created":{"date-parts":[[2009,3,31]],"date-time":"2009-03-31T03:42:22Z","timestamp":1238470942000},"page":"1241-1251","source":"Crossref","is-referenced-by-count":91,"title":["IFN\u2010\u03b3\u2010STAT1 signal regulates the differentiation of inducible Treg: Potential role for ROS\u2010mediated apoptosis"],"prefix":"10.1002","volume":"39","author":[{"given":"Jae\u2010Hoon","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon\u2010Jeong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung\u2010Hee","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010Yuil","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,4,29]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1032"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni816"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/86302"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80195-8"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1160"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1264"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1263"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2006.00414.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1004599"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.4.2041"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.3.1427"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxm139"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0703642104"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.11.5678"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425810"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.11.6526"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.9.4850"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.15.1.749"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.163.9.4647"},{"key":"e_1_2_6_21_2","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.4049\/jimmunol.140.4.1022","article-title":"IFN\u2010gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses","volume":"140","author":"Finkelman F. 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