{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:48:03Z","timestamp":1790930883387,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,3,5]],"date-time":"2009-03-05T00:00:00Z","timestamp":1236211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human invariant NKT (iNKT) cells are a unique subset of T cells, which recognize glycolipids presented by the CD1d. Among the iNKT cells, several functionally distinct subsets have been characterized according to CD4 and\/or CD8 co\u2010receptor expression. The current study is focussed on the CD4<jats:sup>+<\/jats:sup> iNKT cell subset and its role in an anti\u2010infectious response. We have examined the role of CD4<jats:sup>+<\/jats:sup> iNKT cells on the intracellular <jats:italic>Brucella suis<\/jats:italic> growth. Our results indicate that CD4<jats:sup>+<\/jats:sup> iNKT cells impair the intramacrophagic growth of <jats:italic>Brucella<\/jats:italic>. This inhibition is due to a combination of soluble and contact\u2010dependent mechanisms: IFN\u2010\u03b3 is weakly involved while cytotoxic activities such as the induction of the Fas pathway and the release of lytic granules are major mechanisms. The impairment of <jats:italic>Brucella<\/jats:italic> growth by CD4<jats:sup>+<\/jats:sup> iNKT cells requires an interaction with CD1d on macrophage surface. Also, we have shown that although CD4 regulates several biological responses of CD4<jats:sup>+<\/jats:sup> iNKT cells, it is not involved in their antibacterial activity. Here, we have shown for the first time that the CD4<jats:sup>+<\/jats:sup> iNKT cell population has antibacterial activity and thus, participates directly in the elimination of bacteria and\/or in the control of bacterial growth by killing infected cells.<\/jats:p>","DOI":"10.1002\/eji.200838929","type":"journal-article","created":{"date-parts":[[2009,3,5]],"date-time":"2009-03-05T08:45:56Z","timestamp":1236242756000},"page":"1025-1035","source":"Crossref","is-referenced-by-count":23,"title":["Human CD4<sup>+<\/sup> invariant NKT cells are involved in antibacterial immunity against <i>Brucella suis<\/i> through CD1d\u2010dependent but CD4\u2010independent mechanisms"],"prefix":"10.1002","volume":"39","author":[{"given":"St\u00e9phanie","family":"Bessoles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherri","family":"Dudal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurdyal S.","family":"Besra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Lafont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.15.1.535"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.3.1171"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.3.1097"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7538697"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.17.1.297"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5324.339"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5343.1626"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03408"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092009"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611139104"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0607285104"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1657"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03407"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200526157"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408696102"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1380"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403787101"},{"key":"e_1_2_6_19_2","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.4049\/jimmunol.159.5.2240","article-title":"Cultured NK1.1+CD4+T cells produce large amounts of IL\u20104 and IFN\u2010gamma upon activation by anti\u2010CD3 or CD1","volume":"159","author":"Chen H.","year":"1997","journal-title":"J. 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