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IL\u20101 is thus critical for CD4<jats:sup>+<\/jats:sup> Th2\u2010mediated immunity to <jats:italic>T. muris<\/jats:italic>; however, this action is independent of the established IL\u20101 signalling receptor. We also present data demonstrating that both IL\u20101\u03b1 and IL\u20101\u03b2 induce measurable effects on <jats:italic>T. muris<\/jats:italic> primed cells isolated from IL\u20101R1 or IL\u20101R AcP null mice. MLN cells from these mice restimulated with parasite antigen proliferated at a greater rate and produced more cytokines in response to exogenous IL\u20101. This ability to respond to IL\u20101 was restricted to these parasite\u2010primed cells and importantly was not evident in cells from na\u00efve gene null mice. These <jats:italic>in vitro<\/jats:italic> data are consistent with the observed ability of mice with compromised IL\u20101 signalling to expel the parasite, bolstering the premise that an alternative IL\u20101 signalling mechanism is accessible in the context of an intestinal helminth\u2010driven Th2 immune response.<\/jats:p>","DOI":"10.1002\/eji.200838938","type":"journal-article","created":{"date-parts":[[2009,2,26]],"date-time":"2009-02-26T08:09:17Z","timestamp":1235635757000},"page":"1036-1045","source":"Crossref","is-referenced-by-count":20,"title":["IL\u20101\u2010dependent, IL\u20101R1\u2010independent resistance to gastrointestinal nematodes"],"prefix":"10.1002","volume":"39","author":[{"given":"Neil E.","family":"Humphreys","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard K.","family":"Grencis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-119-8-199310150-00013"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.v15.i1.30"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.6.2095.bloodjournal8762095"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"5614","DOI":"10.4049\/jimmunol.161.10.5614","article-title":"IL\u20101 receptor accessory protein is an essential component of the IL\u20101 receptor","volume":"161","author":"Cullinan E. 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