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To investigate the fate of nervous system\u2010specific CD8<jats:sup>+<\/jats:sup> T cells, which only recently came up as being important contributors for MS pathogenesis, we developed a mouse model that allows inducible expression of lymphocytic choriomeningitis virus\u2010derived CD8<jats:sup>+<\/jats:sup> T\u2010cell epitopes specifically in oligodendrocytes and Schwann cells, the myelinating glia of the nervous system. These transgenic CD8<jats:sup>+<\/jats:sup> T\u2010cell epitopes induced robust tolerance of endogenous auto\u2010reactive T cells, which proved thymus\u2010independent and was mediated by cross\u2010presenting bone\u2010marrow\u2010derived cells. Immunohistological staining of secondary lymphoid organs demonstrated the presence of glia\u2010derived antigens in DC, suggesting that peripheral tolerance of CD8<jats:sup>+<\/jats:sup> T cells results from uptake and presentation by steady state DC.<\/jats:p>","DOI":"10.1002\/eji.200839019","type":"journal-article","created":{"date-parts":[[2009,5,21]],"date-time":"2009-05-21T19:07:53Z","timestamp":1242932873000},"page":"1505-1515","source":"Crossref","is-referenced-by-count":9,"title":["Antigens expressed by myelinating glia cells induce peripheral cross\u2010tolerance of endogenous CD8<sup>+<\/sup> T cells"],"prefix":"10.1002","volume":"39","author":[{"given":"Anita","family":"Schildknecht","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans Christian","family":"Probst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy D.","family":"McCoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Miescher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corinne","family":"Brenner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dino P.","family":"Leone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ueli","family":"Suter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela S.","family":"Ohashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maries","family":"van den Broek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,6,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni723"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1075958"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2005.07.006"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021598"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.6.769"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00120-1"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020991"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.6.1174"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf235"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1179\/016164106X98125"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568010053586264"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119539"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.160.3.1532"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.5.669"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.3.1617"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1044-7431(03)00029-0"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.122079599"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/5007"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/32588"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.2.887"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/71540"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.135.2.755"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02072"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.4.1594"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00365-5"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.5.2781"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI19388"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80258-7"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90164-T"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90165-U"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.2.239"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830220421"},{"key":"e_1_2_6_34_2","doi-asserted-by":"crossref","first-page":"723","DOI":"10.4049\/jimmunol.163.2.723","article-title":"Antigen concentration and precursor frequency determine the rate of CD8+ T cell tolerance to peripherally expressed antigens","volume":"163","author":"Morgan D. 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