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Results indicate that CD8<jats:sup>+<\/jats:sup> T cells deficient in IL\u201012 signaling were impaired in clonal expansion after <jats:italic>Listeria monocytogenes<\/jats:italic> infection but not after infection with lymphocytic choriomeningitis virus, vaccinia virus or vesicular stomatitis virus. Although limited in clonal expansion after <jats:italic>Listeria<\/jats:italic> infection, CD8<jats:sup>+<\/jats:sup> T cells deficient in IL\u201012 signaling exhibited normal degranulation activity, cytolytic functions, and secretion of IFN\u2010\u03b3 and TNF\u2010\u03b1. However, CD8<jats:sup>+<\/jats:sup> T cells lacking IL\u201012 signaling failed to up\u2010regulate KLRG1 and to down\u2010regulate CD127 in the context of <jats:italic>Listeria<\/jats:italic> but not viral infections. Thus, direct IL\u201012 signaling to CD8<jats:sup>+<\/jats:sup> T cells determines the cell fate decision between short\u2010lived effector cells and memory precursor effector cells, which is dependent on pathogen\u2010induced local cytokine milieu.<\/jats:p>","DOI":"10.1002\/eji.200839093","type":"journal-article","created":{"date-parts":[[2009,6,22]],"date-time":"2009-06-22T13:57:09Z","timestamp":1245679029000},"page":"1774-1783","source":"Crossref","is-referenced-by-count":58,"title":["Effector T\u2010cell differentiation during viral and bacterial infections: Role of direct IL\u201012 signals for cell fate decision of CD8<sup>+<\/sup> T cells"],"prefix":"10.1002","volume":"39","author":[{"given":"Selina J.","family":"Keppler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Theil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smiljka","family":"Vucikuja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Aichele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,7,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8009221"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.161.4.1947"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80614-7"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.162.2.965"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80413-6"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.1.39"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830260722"},{"key":"e_1_2_6_9_2","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.4049\/jimmunol.153.6.2533","article-title":"Parasite\u2010induced IL\u201012 stimulates early IFN\u2010gamma synthesis and resistance during acute infection with Toxoplasma gondii","volume":"153","author":"Gazzinelli R. 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