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It has been shown that self\u2010specific CD8<jats:sup>+<\/jats:sup> T cells developed in male H\u2010Y antigen\u2010specific TCR transgenic mice share many similarities with naturally occurring MP CD8<jats:sup>+<\/jats:sup> T cells in normal mice. In this study, we found that H\u2010Y antigen\u2010specific CD8<jats:sup>+<\/jats:sup> T cells in male but not female mice decreased when they were crossed with IL\u201015\u2010deficient mice, mainly due to impaired peripheral maintenance. The self\u2010specific TCR transgenic CD8<jats:sup>+<\/jats:sup> T cells developed in IL\u201015\u2010deficient mice showed altered surface phenotypes and reduced effector functions <jats:italic>ex vivo<\/jats:italic>. Bystander activation of the self\u2010specific CD8<jats:sup>+<\/jats:sup> T cells was induced <jats:italic>in vivo<\/jats:italic> during infection with <jats:italic>Listeria monocytogenes<\/jats:italic>, in which proliferation but not IFN\u2010\u03b3 production was IL\u201015\u2010dependent. These results indicated important roles for IL\u201015 in the maintenance and functions of self\u2010specific CD8<jats:sup>+<\/jats:sup> T cells, which may be included in the naturally occurring MP CD8<jats:sup>+<\/jats:sup> T\u2010cell population in na\u00efve normal mice and participate in innate host defense responses.<\/jats:p>","DOI":"10.1002\/eji.200839106","type":"journal-article","created":{"date-parts":[[2009,6,18]],"date-time":"2009-06-18T12:20:16Z","timestamp":1245327616000},"page":"1784-1793","source":"Crossref","is-referenced-by-count":21,"title":["IL\u201015 is critical for the maintenance and innate functions of self\u2010specific CD8<sup>+<\/sup> T 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