{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:34:21Z","timestamp":1767339261438},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,3,8]],"date-time":"2010-03-08T00:00:00Z","timestamp":1268006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Memory cross\u2010reactive CD8<jats:sup>+<\/jats:sup> T\u2010cell responses may induce protection or immunopathology upon secondary viral challenge. To elucidate the potential role of T cells in sequential flavivirus infection, we characterized cross\u2010reactive CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> T\u2010cell responses between attenuated and pathogenic Japanese encephalitis virus (JEV) and pathogenic West Nile virus (WNV). A previously reported WNV NS4b CD8<jats:sup>+<\/jats:sup> T\u2010cell epitope and its JEV variant elicited CD8<jats:sup>+<\/jats:sup> T\u2010cell responses in both JEV\u2010 and WNV\u2010infected mice. The peptide variant homologous to the immunizing virus induced greater cytokine secretion and activated higher frequencies of epitope\u2010specific CD8<jats:sup>+<\/jats:sup> T cells. However, there was a virus\u2010dependent, peptide variant\u2010independent pattern of cytokine secretion; the IFN\u03b3<jats:sup>+<\/jats:sup>\u2010to\u2010IFN\u03b3<jats:sup>+<\/jats:sup>TNF\u03b1<jats:sup>+<\/jats:sup> CD8<jats:sup>+<\/jats:sup> T\u2010cell ratio was greater in JEV\u2010 than in WNV\u2010infected mice. Despite similarities in viral burden for pathogenic WNV and JEV viruses, CD8<jats:sup>+<\/jats:sup> T cells from pathogenic JEV\u2010immunized mice exhibited functional and phenotypic profiles similar to those seen for the attenuated JEV strain. Patterns of killer cell lectin\u2010like receptor G1 (KLRG1) and CD127 expression differed by virus type, with a rapid expansion and contraction of short\u2010lived effector cells in JEV infection and persistence of high levels of short\u2010lived effector cells in WNV infection. Such cross\u2010reactive T\u2010cell responses to primary infection may affect the outcomes of sequential flavivirus infections.<\/jats:p>","DOI":"10.1002\/eji.200839108","type":"journal-article","created":{"date-parts":[[2010,3,8]],"date-time":"2010-03-08T12:09:20Z","timestamp":1268050160000},"page":"1315-1327","source":"Crossref","is-referenced-by-count":17,"title":["Altered effector functions of virus\u2010specific and virus cross\u2010reactive CD8<sup>+<\/sup> T cells in mice immunized with related flaviviruses"],"prefix":"10.1002","volume":"40","author":[{"given":"Derek W.","family":"Trobaugh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis A.","family":"Ennis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharone","family":"Green","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,4,29]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1144"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)05967-0"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-77-4-705"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.4.2578-2586.2003"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.15.8312-8321.2004"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01650-06"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737196"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737192"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.12.8568"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.9.1705"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni727"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0803.010238"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(03)00507-3"},{"key":"e_1_2_6_15_2","first-page":"277","article-title":"Two\u2010way cross\u2010protection between West Nile and Japanese encephalitis viruses in bonnet macaques","volume":"36","author":"Goverdhan M. 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