{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:45:46Z","timestamp":1790520346184,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,4,19]],"date-time":"2010-04-19T00:00:00Z","timestamp":1271635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recent studies have suggested Fas\u2010mediated elimination of antigen\u2010presenting cells as an important mechanism down\u2010regulating the induction of autoimmune responses. It remains unknown whether this mechanism restricts the magnitude of immune responses to non\u2010self antigens. We used a mouse model of a cutaneous CD8<jats:sup>+<\/jats:sup> T\u2010cell\u2010mediated immune response (contact hypersensitivity, CHS) to test if CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup> T cells expressing FasL regulate hapten\u2010specific effector CD8<jats:sup>+<\/jats:sup> T cell expansion through the elimination of Fas\u2010expressing hapten\u2010presenting DC. In WT mice, attenuation of CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup> T regulatory cell activity by anti\u2010CD25 mAb increased hapten\u2010presenting DC numbers in skin\u2010draining LN, which led to increased effector CD8<jats:sup>+<\/jats:sup> T\u2010cell priming for CHS responses. In contrast, CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup> T cells did not regulate hapten\u2010specific CD8<jats:sup>+<\/jats:sup> T\u2010cell priming and CHS responses initiated by Fas\u2010defective (<jats:italic>lpr<\/jats:italic>) DC. Thus, restricting DC priming functions through Fas\u2013FasL interactions is a potent mechanism employed by CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup> regulatory cells to restrict CD8<jats:sup>+<\/jats:sup> T\u2010cell\u2010mediated allergic immune responses in the skin.<\/jats:p>","DOI":"10.1002\/eji.200939387","type":"journal-article","created":{"date-parts":[[2010,4,19]],"date-time":"2010-04-19T17:50:46Z","timestamp":1271699446000},"page":"2006-2015","source":"Crossref","is-referenced-by-count":25,"title":["CD4<sup>+<\/sup>CD25<sup>+<\/sup> regulatory T cells utilize FasL as a mechanism to restrict DC priming functions in cutaneous immune responses"],"prefix":"10.1002","volume":"40","author":[{"given":"Anton V.","family":"Gorbachev","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Fairchild","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,6,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.4.2286"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"5287","DOI":"10.4049\/jimmunol.162.9.5287","article-title":"Dendritic cells undergo rapid apoptosis in vitro during antigen\u2010specific interaction with CD4+ T cells","volume":"162","author":"Matsue H.","year":"1999","journal-title":"J. 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