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We found that endogenously activated pleural fluid\u2010derived NK cells express high ICAM\u20101 levels and induce T\u2010cell activation <jats:italic>ex vivo<\/jats:italic> through ICAM\u20101. Besides, upon <jats:italic>in vitro<\/jats:italic> stimulation with monokines and PAMP, resting peripheral blood NK cells increased ICAM\u20101 expression leading to cellular activation and Th1 polarization of autologous T cells. Furthermore, these effects were abolished by anti\u2010ICAM\u20101 Ab. Hence, NK cells may contribute to the adaptive immune response by a direct cell\u2010contact\u2010dependent mechanism in the context of <jats:italic>Mycobacterium tuberculosis<\/jats:italic> infection.<\/jats:p>","DOI":"10.1002\/eji.200939515","type":"journal-article","created":{"date-parts":[[2009,8,27]],"date-time":"2009-08-27T17:11:49Z","timestamp":1251393109000},"page":"2450-2458","source":"Crossref","is-referenced-by-count":14,"title":["NK cells from tuberculous pleurisy express high ICAM\u20101 levels and exert stimulatory effect on local T cells"],"prefix":"10.1002","volume":"39","author":[{"given":"Pablo","family":"Schierloh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noem\u00ed","family":"Yokobori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Geffner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Balboa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda M.","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa M.","family":"Musella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Alem\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Castagnino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Basile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia S.","family":"de la Barrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Abbate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda C.","family":"Sasiain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,8,27]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"9","article-title":"Pathophysiology of pleural space infections","volume":"14","author":"Antony V. 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