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In this study, we addressed this question by measuring cross\u2010presentation as well as cross\u2010priming by virus\u2010like particles (VLP) displaying peptide p33 derived of lymphocytic choriomeningitis virus. Innate stimuli were varied by either packaging different TLR ligands into virus\u2010like particles or using mice deficient in two key molecules of TLR\u2010signaling, namely the adaptor molecule MyD88 as well as IFN\u2010\u03b1\/\u03b2 receptor. While efficient cross\u2010presentation occurred despite strongly reduced activation of DC in the absence of TLR ligand\u2010mediated signals, T\u2010cell priming was abolished. Thus, innate stimuli regulate cross\u2010priming at the level of DC licensing for T\u2010cell activation and not antigen presentation.<\/jats:p>","DOI":"10.1002\/eji.200939559","type":"journal-article","created":{"date-parts":[[2009,10,29]],"date-time":"2009-10-29T16:34:21Z","timestamp":1256834061000},"page":"103-112","source":"Crossref","is-referenced-by-count":29,"title":["Innate signaling regulates cross\u2010priming at the level of DC licensing and not antigen presentation"],"prefix":"10.1002","volume":"40","author":[{"given":"Susanne A.","family":"Keller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vania","family":"Manolova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline E.","family":"von Allmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias G.","family":"Kinzler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Muntwiler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Saudan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin F.","family":"Bachmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,12,30]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/342478a0"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/18038"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1999.tb01359.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.6.2880"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","first-page":"438","DOI":"10.4049\/jimmunol.150.2.438","article-title":"Characterization of antigen\u2010presenting cells that present exogenous antigens in association with class I MHC molecules","volume":"150","author":"Rock K. 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