{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:04:12Z","timestamp":1791651852130,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,11,25]],"date-time":"2009-11-25T00:00:00Z","timestamp":1259107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>IL\u201010 is a potent regulator of the innate and adaptive immune responses. Several cell types produce IL\u201010 and its receptor chains and these may regulate different immune responses. Here we report that inactivation of the IL\u201010 receptor (IL\u201010R1) gene in mice leads to an increased susceptibility to chemically induced colitis as in the classical IL\u201010\u2010deficient mutant. To identify the cells regulated by IL\u201010 in immune responses, we generated several cell type specific IL\u201010R1\u2010deficient mutants. We show that, in an IL\u201010\u2010dependent LPS model of endotoxemia, dampening of the immune response requires expression of IL\u201010R1 in monocytes\/macrophages and\/or neutrophils but not in T cells nor B cells. As the macrophage and\/or neutrophil\u2010specific IL\u201010\u2010deficient mutants also display the same phenotype, our results suggest that an autocrine loop in monocytes\/macrophages is the most probable mechanism for the regulation of an LPS\u2010induced septic shock. In contrast, in an IL\u201010\u2010regulated T\u2010cell response to <jats:italic>Trichuris muris<\/jats:italic> infection, IL\u201010 acting on T cells or monocytes\/macrophages\/neutrophils is not critical for the control of the infection.<\/jats:p>","DOI":"10.1002\/eji.200939592","type":"journal-article","created":{"date-parts":[[2009,11,25]],"date-time":"2009-11-25T22:59:28Z","timestamp":1259189968000},"page":"443-448","source":"Crossref","is-referenced-by-count":108,"title":["Monocytes\/macrophages and\/or neutrophils are the target of IL\u201010 in the LPS endotoxemia model"],"prefix":"10.1002","volume":"40","author":[{"given":"Marina C.","family":"Pils","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Pisano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Fasnacht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan\u2010Michael","family":"Heinrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lothar","family":"Groebe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Schippers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Rozell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Jack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,1,26]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.02.017"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636012"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.19.1.683"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)80068-P"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907206"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0204117"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118290"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(04)57004-5"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.5.2383"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00227-8"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.6.1317"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008942828960"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/gene.20016"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1258\/la.2009.0080075"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0020243"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1995.tb00091.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365529850171080"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-07-2465"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020732"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041789"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.147.11.3815"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2005.05.002"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200838331"},{"key":"e_1_2_6_25_2","first-page":"2008 E 1398","article-title":"Analysis of infection of mice with Trichuris muris","author":"Fasnacht N.","year":"2008","journal-title":"Hannover Med. 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