{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:39:40Z","timestamp":1791275980246,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2009,10,14]],"date-time":"2009-10-14T00:00:00Z","timestamp":1255478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Salmonella<\/jats:italic> are important intracellular pathogens in humans and other animal hosts. IL\u201024 is a novel tumour suppressor and can mediate induction of Th1\u2010type cytokines from PBMC. However, the immunological consequences of this cytokine during intracellular pathogen infection <jats:italic>in vivo<\/jats:italic> remain unclear. In the present study, we used a virulent <jats:italic>S. typhimurium<\/jats:italic> C5 infected mouse model of typhoid fever to demonstrate that administration of exogenous IL\u201024 had a protective effect against the bacteria. The IL\u201024 glycosylation site mutant, in contrast, showed a decreased protective effect. Furthermore, the protective effect of IL\u201024 was abrogated in IFN\u2010\u03b3 KO mice. More importantly, we demonstrated that IL\u201024 predominately stimulated neutrophils to produce IFN\u2010\u03b3 and IL\u201012, subsequently activating CD8<jats:sup>+<\/jats:sup> T cells both <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic>. In addition, IL\u201024 could induce neutrophils to produce NO. These data indicate that the neutrophils activated by IL\u201024 may play important roles in host defence against <jats:italic>Salmonella<\/jats:italic> infection <jats:italic>in vivo<\/jats:italic>. Our findings support the development of a novel cytokine immunotherapy against <jats:italic>Salmonella<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/eji.200939678","type":"journal-article","created":{"date-parts":[[2009,10,14]],"date-time":"2009-10-14T17:53:38Z","timestamp":1255542818000},"page":"3357-3368","source":"Crossref","is-referenced-by-count":45,"title":["IL\u201024 protects against <i>Salmonella typhimurium<\/i> infection by stimulating early neutrophil Th1 cytokine production, which in turn activates CD8<sup>+<\/sup> T cells"],"prefix":"10.1002","volume":"39","author":[{"given":"Yunfeng","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haidan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qilong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengling","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Lian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,12]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001432-200210000-00009"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2007.10.003"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020201"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060465"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2005.12.011"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2008.03.012"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1743"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.10.4052-4060.2005"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425523"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1078\/0171-2985-00135"},{"key":"e_1_2_6_12_2","first-page":"2477","article-title":"Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda\u20107, modulated during human melanoma differentiation, growth and progression","volume":"11","author":"Jiang H.","year":"1995","journal-title":"Oncogen"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204897"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03401847"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804089105"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.12.6041"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200738056"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro955"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01879-06"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.9.5304"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1887"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.291.5512.2370"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.01.049"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2003.08.009"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004360050030"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2004.09.016"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(01)01483-6"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1645\/GE-976R.1"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0902770106"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.8.4450"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.2003.01330.x"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.4.2734"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.10.5859"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.08.009"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700148"},{"key":"e_1_2_6_36_2","doi-asserted-by":"crossref","first-page":"5145","DOI":"10.4049\/jimmunol.160.10.5145","article-title":"IFN\u2010gamma is produced by polymorphonuclear neutrophils in human uterine endometrium and by cultured peripheral blood polymorphonuclear neutrophils","volume":"160","author":"Yeaman G. 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