{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:24:42Z","timestamp":1791192282179,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,1,8]],"date-time":"2010-01-08T00:00:00Z","timestamp":1262908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic helminth infections induce T\u2010cell hyporesponsiveness, which may affect immune responses to other pathogens or to vaccines. This study investigates the influence of Treg activity on proliferation and cytokine responses to BCG and <jats:italic>Plasmodium falciparum<\/jats:italic>\u2010parasitized RBC in Indonesian schoolchildren. Geohelminth\u2010infected children's <jats:italic>in vitro<\/jats:italic> T\u2010cell proliferation to either BCG or pRBC was reduced compared to that of uninfected children. Although the frequency of CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>hi<\/jats:sup>FOXP3<jats:sup>+<\/jats:sup> T cells was similar regardless of infection status, the suppressive activity differed between geohelminth\u2010infected and geohelminth\u2010uninfected groups: Ag\u2010specific proliferative responses increased upon CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>hi<\/jats:sup> T\u2010cell depletion in geohelminth\u2010infected subjects only. In addition, IFN\u2010\u03b3 production in response to both BCG and parasitized RBC was increased after removal of CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>hi<\/jats:sup> T cells. These data demonstrate that geohelminth\u2010associated Treg influence immune responses to bystander Ag of mycobacteria and plasmodia. Geohelminth\u2010induced immune modulation may have important consequences for co\u2010endemic infections and vaccine trials.<\/jats:p>","DOI":"10.1002\/eji.200939699","type":"journal-article","created":{"date-parts":[[2010,1,8]],"date-time":"2010-01-08T20:56:01Z","timestamp":1262984161000},"page":"437-442","source":"Crossref","is-referenced-by-count":127,"title":["Regulatory T cells in human geohelminth infection suppress immune responses to BCG and <i>Plasmodium falciparum<\/i>"],"prefix":"10.1002","volume":"40","author":[{"given":"Linda J.","family":"Wammes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firdaus","family":"Hamid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aprilianto E.","family":"Wiria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brechje","family":"de Gier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erliyani","family":"Sartono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick M.","family":"Maizels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian J. F.","family":"Luty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Filli\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary T.","family":"Brice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taniawati","family":"Supali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermelijn H.","family":"Smits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Yazdanbakhsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,1,26]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/365797a0"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200738120"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2007.77.676"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.5.3248"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2007.03.009"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.04.083"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.3.1574-1580.2001"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2005.06.011"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/598687"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60210-4"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2008.02.009"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000255"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.1.92"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031579"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Feji.200939699","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eji.200939699","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T23:09:39Z","timestamp":1698707379000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.200939699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,26]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["10.1002\/eji.200939699"],"URL":"https:\/\/doi.org\/10.1002\/eji.200939699","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,26]]}}}