{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:33:16Z","timestamp":1791214396099,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,3,3]],"date-time":"2010-03-03T00:00:00Z","timestamp":1267574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The killer cell lectin\u2010like receptor G1 (KLRG1) is expressed by NK and T\u2010cell subsets and recognizes members of the classical cadherin family. KLRG1 is widely used as a lymphocyte differentiation marker in both humans and mice but the physiological role of KLRG1 <jats:italic>in vivo<\/jats:italic> is still unclear. Here, we generated KLRG1\u2010deficient mice by homologous recombination and used several infection models for their characterization. The results revealed that KLRG1 deficiency did not affect development and function of NK cells examined under various conditions. KLRG1 was also dispensable for normal CD8<jats:sup>+<\/jats:sup> T\u2010cell differentiation and function after viral infections. Thus, KLRG1 is a marker for distinct NK and T\u2010cell differentiation stages but it does not play a deterministic role in the generation and functional characteristics of these lymphocyte subsets. In addition, we demonstrate that E\u2010cadherin expressed by K562 target cells inhibited NK\u2010cell reactivity in transgenic mice over\u2010expressing KLRG1 but not in KLRG1\u2010deficient or WT mice. Hence, the inhibitory potential of KLRG1 in mice is rather weak and strong activation signals during viral infections may override the inhibitory signal <jats:italic>in vivo<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/eji.200939771","type":"journal-article","created":{"date-parts":[[2010,3,3]],"date-time":"2010-03-03T20:19:56Z","timestamp":1267647596000},"page":"1303-1314","source":"Crossref","is-referenced-by-count":57,"title":["The NK receptor KLRG1 is dispensable for virus\u2010induced NK and CD8<sup>+<\/sup> T\u2010cell differentiation and function <i>in vivo<\/i>"],"prefix":"10.1002","volume":"40","author":[{"given":"Carsten","family":"Gr\u00fcndemann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Schwartzkopff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Koschella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Schweier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Voehringer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanspeter","family":"Pircher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,4,29]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199811)28:11<3755::AID-IMMU3755>3.0.CO;2-3"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002510000282"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.20.9397"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"4324","DOI":"10.4049\/jimmunol.141.12.4324","article-title":"A monoclonal antibody that inhibits secretion from rat basophilic leukemia cells and binds to a novel membrane component","volume":"141","author":"Ortega Soto E.","year":"1988","journal-title":"J. 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