{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:20:37Z","timestamp":1791300037475,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,3,29]],"date-time":"2010-03-29T00:00:00Z","timestamp":1269820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human autoimmune diseases are often characterized by a relative deficiency in CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup> regulatory T cells (Treg). We therefore hypothesized that expansion of Treg can ameliorate autoimmune pathology. We tested this hypothesis in an experimental model for autoimmune myasthenia gravis (MG), a B\u2010cell\u2010mediated disease characterized by auto\u2010Ab directed against the acetylcholine receptor within neuromuscular junctions. We showed that injection of immune complexes composed of the cytokine IL\u20102 and anti\u2010IL\u20102 mAb (JES6\u20101A12) induced an effective and sustained expansion of Treg, <jats:italic>via<\/jats:italic> peripheral proliferation of CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup>Foxp3<jats:sup>+<\/jats:sup> cells and peripheral conversion of CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>\u2212<\/jats:sup>Foxp3<jats:sup>\u2212<\/jats:sup> cells. The expanded Treg potently suppressed autoreactive T\u2010 and B\u2010cell responses to acetylcholine receptor and attenuated the muscular weakness that is characteristic of MG. Thus, IL\u20102\/anti\u2010IL\u20102 mAb complexes can expand functional Treg <jats:italic>in vivo<\/jats:italic>, providing a potential clinical application of this modality for treatment of MG and other autoimmune disorders.<\/jats:p>","DOI":"10.1002\/eji.200939792","type":"journal-article","created":{"date-parts":[[2010,3,29]],"date-time":"2010-03-29T13:40:22Z","timestamp":1269870022000},"page":"1577-1589","source":"Crossref","is-referenced-by-count":96,"title":["Expansion of regulatory T cells <i>via<\/i> IL\u20102\/anti\u2010IL\u20102 mAb complexes suppresses experimental myasthenia"],"prefix":"10.1002","volume":"40","author":[{"given":"Ruolan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"La Cava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise I.","family":"Campagnolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Van Kaer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu\u2010Dong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,6,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1564"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1178"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1184"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2006.05.003"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-11-3900"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0300-9475.2004.01410.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2007.10.001"},{"key":"e_1_2_6_9_2","first-page":"54","article-title":"Circulating CD4+CD25+ T regulatory and natural killer T cells in patients with myasthenia gravis: a flow cytometry study","volume":"19","author":"Battaglia A.","year":"2005","journal-title":"J. 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